Receptor Mediated Actions on Effector Organs & Anticholinergic Actions Flashcards by Catherine Atkinson

Sympathetic or parasympathetic and what receptor?

Contraction of iris radial muscle (pupil dilates)

α1 (SNS)

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Contraction of iris spinchter muscle (pupil contracts)

M (PNS)

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Contraction of ciliary muscle (lens accomodates for near vision)

M (PNS)

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Trachea & Bronchioles Dilate

β2 (SNS)

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Trachea & Bronchioles constricts, increases secretions

M (PNS)

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Epinepherine and NE secreted from the adrenal medulla

Nn (SNS)

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Secretion of renin from the kidneys (increases)

β1 (SNS)

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Secretion of renin from the kidneys (decreases)

α1 (SNS)

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Relaxes detrusor (detrusor remains relaxed to allow the bladder to store urine, and contracts during urination to release urine)

β2 (SNS)

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Contraction of trigone (bladder floor that detects when bladder is full)

α1 (SNS)

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Contraction of detrousor; relaxation of trigone and spinchter

M (PNS)

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Stimulates ejaculation

α1 (SNS)

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Stimulates ejection

M (PNS)

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Stimulates tears

M (PNS)

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Thick, viscid secretion from salivary glands

α1 (SNS)

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Copious, watery secretion from salivary glands

M (PNS)

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Increased HR and contractility

β1 (SNS)

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Decreased rate and contractility

M2 (PNS)

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Decrease in muscle motility and tone

β2 (SNS)

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Contraction of spinchters

α1 (SNS)

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Increased muscle motility and tone

M (PNS)

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Relaxation of ureters

β2 (SNS)

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Dilatation of skeletal muscles

β2 (SNS)

Constriction of blood vessels

α1 (SNS)

Muscarinic receptors are located on which 4 postganglioninc organs?

- Respiratory (bronchial muscle contraction) - GI tract - GU tract - Eye (miosis- constriction and accomodation and dec IOP)

Mnemonic for activation of muscarinic receptors

BB SLUDGE

Nicotinic neuronal receptors are found at which three places?

Cardiovascular, GI/urinary tract, and brain

What receptors does nicotine stimulate?

Nicotonic neuronal (both PSNS and SNS stimulation)

Glaucoma is treated with this cholinergic med?

Pilocarpine (constricts pupil)

These two drugs are cholinergic used in urinary retention?

bethanechol & neostigimine

How do you treat the SLUDGE side effects of cholinergic meds?

Atropine

What are three cholinergic (indirect) medications used to treat myasthenia gravis?

Edorphonium, neostigmine, pyridostigmine

If you want to block muscarinic side effects caused by cholinergic meds, what can be given in addition?

Neostigmine + atropine to decrease BB SLUDGE s/e

What cholinergic indirect agonist med is used in alzheimer's disease?

Donepezil

Lethal exposures of AChEIs cause what acronym and effects?

BB SLUDGE where BB dominates and causes toxic exposure- has to be treated immediately.

Lethal exposure of Nn can cause what bad side effect?

seizures

Lethal exposure of Nm can cause what bad side effect?

fasiculations, weakness, muscle paralysis

What type of cholinergic receptor involves ion channels?

Nicotinic

What type of cholinergic receptor involves G-proteins?

Muscarinic

Name three DIRECT cholinergic meds and if they are muscarinic or nicotinic

"Pilo & Beth Need" - Pilocarpine (M) - Bethanechol (M) - Nicotine (N)

Name four INDIRECT cholinergic meds

"Need Pretty Damn Efficent Organs" - Neostigmine (i) - Physostigmine (i) - Donepizil (i) - Edrophium (i) - Organophosphates (i)

Name 4 antimuscarinic ANTIcholinergic drugs?

"A saggy old titty" - Atropine (M) - Scopolamine (M) - Oxybutinyn (M) - Tolterodine (M)

Name three antinicotinic ANTIcholinergic neuromuscular blockers?

"A runny shit" - Atracurium (Nm) - Rocurium (Nm) - Succinylcholine (Nm)

This cholinergic med facilitates Ach breakdown and can be used to counteract nerve gas poisioning?

Pralixodime (d in dime for breakDown)

This cholinergic med blocks Ach and can be used to counteract nerve gas poisioning and the BB in BB SLUDGE?

Atropine

This cholinergic med can be used to treat convulsions?

Diazepam

What two anticholinergics are used for COPD and asthma?

Ipratropium, tiotropium "piums"

What two anticholinergic drugs are used for GI hypermotility (cramping)

Dicyclomine, propantheline ("ines"

What anticholinergic med is used for severe bradycardia?

Atropine "BB" in BBSLUDGE

What anticholinergic med is used for symptomatic relief of rhinorrhea?

Ipratropium

What anticholinergic med is used to treat overactive bladder?

oxybutynin and tolterodine

This medication is a beta3 agonist and is used to relax the bladder smooth muscle and is an option for patients that can't tolerate antimuscarinic side effects

Mirabegron

This med is used as an adjunctive treatment of Parkinson's disease

Benztropine

This med is used in the prevention of motion sickness

scopolamine

This antihistamine med is used in motion sickness that is milder and of longer duration

dimenhydrinate

What are the adverse reactions of anti-cholinergic meds?

No see, no pee, no spit, no shit & tachycardia also sedation