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pharmaEx2 > Receptor Mediated Actions on Effector Organs & Anticholinergic Actions > Flashcards

Receptor Mediated Actions on Effector Organs & Anticholinergic Actions Flashcards

1
Q

Sympathetic or parasympathetic and what receptor?

Contraction of iris radial muscle (pupil dilates)

A

α1 (SNS)

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2
Q

Contraction of iris spinchter muscle (pupil contracts)

A

M (PNS)

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3
Q

Contraction of ciliary muscle (lens accomodates for near vision)

A

M (PNS)

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4
Q

Trachea & Bronchioles Dilate

A

β2 (SNS)

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5
Q

Trachea & Bronchioles constricts, increases secretions

A

M (PNS)

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6
Q

Epinepherine and NE secreted from the adrenal medulla

A

Nn (SNS)

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7
Q

Secretion of renin from the kidneys (increases)

A

β1 (SNS)

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8
Q

Secretion of renin from the kidneys (decreases)

A

α1 (SNS)

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9
Q

Relaxes detrusor (detrusor remains relaxed to allow the bladder to store urine, and contracts during urination to release urine)

A

β2 (SNS)

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10
Q

Contraction of trigone (bladder floor that detects when bladder is full)

A

α1 (SNS)

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11
Q

Contraction of detrousor; relaxation of trigone and spinchter

A

M (PNS)

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12
Q

Stimulates ejaculation

A

α1 (SNS)

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13
Q

Stimulates ejection

A

M (PNS)

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14
Q

Stimulates tears

A

M (PNS)

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15
Q

Thick, viscid secretion from salivary glands

A

α1 (SNS)

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16
Q

Copious, watery secretion from salivary glands

A

M (PNS)

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17
Q

Increased HR and contractility

A

β1 (SNS)

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18
Q

Decreased rate and contractility

A

M2 (PNS)

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19
Q

Decrease in muscle motility and tone

A

β2 (SNS)

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20
Q

Contraction of spinchters

A

α1 (SNS)

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21
Q

Increased muscle motility and tone

A

M (PNS)

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22
Q

Relaxation of ureters

A

β2 (SNS)

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23
Q

Dilatation of skeletal muscles

A

β2 (SNS)

24
Q

Constriction of blood vessels

A

α1 (SNS)

25
Q

Muscarinic receptors are located on which 4 postganglioninc organs?

A
  • Respiratory (bronchial muscle contraction)
  • GI tract
  • GU tract
  • Eye (miosis- constriction and accomodation and dec IOP)
26
Q

Mnemonic for activation of muscarinic receptors

A

BB SLUDGE

27
Q

Nicotinic neuronal receptors are found at which three places?

A

Cardiovascular, GI/urinary tract, and brain

28
Q

What receptors does nicotine stimulate?

A

Nicotonic neuronal (both PSNS and SNS stimulation)

29
Q

Glaucoma is treated with this cholinergic med?

A

Pilocarpine (constricts pupil)

30
Q

These two drugs are cholinergic used in urinary retention?

A

bethanechol & neostigimine

31
Q

How do you treat the SLUDGE side effects of cholinergic meds?

A

Atropine

32
Q

What are three cholinergic (indirect) medications used to treat myasthenia gravis?

A

Edorphonium, neostigmine, pyridostigmine

33
Q

If you want to block muscarinic side effects caused by cholinergic meds, what can be given in addition?

A

Neostigmine + atropine to decrease BB SLUDGE s/e

34
Q

What cholinergic indirect agonist med is used in alzheimer’s disease?

A

Donepezil

35
Q

Lethal exposures of AChEIs cause what acronym and effects?

A

BB SLUDGE where BB dominates and causes toxic exposure- has to be treated immediately.

36
Q

Lethal exposure of Nn can cause what bad side effect?

A

seizures

37
Q

Lethal exposure of Nm can cause what bad side effect?

A

fasiculations, weakness, muscle paralysis

38
Q

What type of cholinergic receptor involves ion channels?

A

Nicotinic

39
Q

What type of cholinergic receptor involves G-proteins?

A

Muscarinic

40
Q

Name three DIRECT cholinergic meds and if they are muscarinic or nicotinic

A

“Pilo & Beth Need”

  • Pilocarpine (M)
  • Bethanechol (M)
  • Nicotine (N)
41
Q

Name four INDIRECT cholinergic meds

A

“Need Pretty Damn Efficent Organs”

  • Neostigmine (i)
  • Physostigmine (i)
  • Donepizil (i)
  • Edrophium (i)
  • Organophosphates (i)
42
Q

Name 4 antimuscarinic ANTIcholinergic drugs?

A

“A saggy old titty”

  • Atropine (M)
  • Scopolamine (M)
  • Oxybutinyn (M)
  • Tolterodine (M)
43
Q

Name three antinicotinic ANTIcholinergic neuromuscular blockers?

A

“A runny shit”

  • Atracurium (Nm)
  • Rocurium (Nm)
  • Succinylcholine (Nm)
44
Q

This cholinergic med facilitates Ach breakdown and can be used to counteract nerve gas poisioning?

A

Pralixodime (d in dime for breakDown)

45
Q

This cholinergic med blocks Ach and can be used to counteract nerve gas poisioning and the BB in BB SLUDGE?

A

Atropine

46
Q

This cholinergic med can be used to treat convulsions?

A

Diazepam

47
Q

What two anticholinergics are used for COPD and asthma?

A

Ipratropium, tiotropium

“piums”

48
Q

What two anticholinergic drugs are used for GI hypermotility (cramping)

A

Dicyclomine, propantheline (“ines”

49
Q

What anticholinergic med is used for severe bradycardia?

A

Atropine “BB” in BBSLUDGE

50
Q

What anticholinergic med is used for symptomatic relief of rhinorrhea?

A

Ipratropium

51
Q

What anticholinergic med is used to treat overactive bladder?

A

oxybutynin and tolterodine

52
Q

This medication is a beta3 agonist and is used to relax the bladder smooth muscle and is an option for patients that can’t tolerate antimuscarinic side effects

A

Mirabegron

53
Q

This med is used as an adjunctive treatment of Parkinson’s disease

A

Benztropine

54
Q

This med is used in the prevention of motion sickness

A

scopolamine

55
Q

This antihistamine med is used in motion sickness that is milder and of longer duration

A

dimenhydrinate

56
Q

What are the adverse reactions of anti-cholinergic meds?

A

No see, no pee, no spit, no shit & tachycardia also sedation

pharmaEx2 (3 decks)

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