receptor mechanisms Flashcards
what do indogenous neurotransmitters/ hormone do
they occupy a receptor (affinity) and cause a biological response (efficacy) - (like a lock and key)
an exogenous agonist
will be different in shape slightly but will mimic the indogenous response
an antagonist
will stop the indogenous from binding by occupying the receptor (affinity) but causes no response (no efficacy)
what are the four superfamilies of receptors
ligand gated ion channels (fast)
G protein coupled receptors (slow)
Tyrosine kinase linked
Nuclear receptors
what is the difference between ANS neurones and somatic NS
ANS has neurones that are in series, synapsed at the ganglia
what can ANS initiate
both fast and slow responses
what type of receptors are nicotinic receptors
ligand gated ion channels (fast)
what type of receptors are Muscurinic receptors
G protein coupled receptors
how many transmembrane domains and proteins do nicotinic receptors have
4 transmembrane domains - TMD2 which as deep groove
5 proteins
what proteins are nACH muscle receptors made from
two alpha proteins
one beta proteins
one gamma protein
one delta / epsilon in embryos
what proteins are nACH in nerves made from
alpha proteins
beta proteins
what does binding of Ach result in
an excretory junction potential (influx of cations)
what do inhibitory ligand gated ion channels do
allow anions to enter
how many subunits does GABAa have
alpha, beta and gamma subunit (with 6 subtypes of each)
what units do benzodiazepines bind to
Gamma
