receptor mechanisms 2 Flashcards
1
Q
how many transmembrane domains and proteins do muscurinic receptors have
A
7 transmembrane domains
1 protein
2
Q
what is their structure
A
Alpha subunit with GDP (replaced by GTP when agonist bound) bound at the bottom and gamma and beta subunits bound at the top
3
Q
what do Gs alpha sub units do
A
stimulate adynyle cyclase
4
Q
what do Gi alpha sub units do
A
inhibit adynyle cyclase
5
Q
what do Gq/11 alpha sub units do
A
stimulate phosopholipase c
6
Q
What is cAMP broken down by
A
phosphodiesterase
7
Q
what type of receptors are beta 1 adrenoceptors
A
G protein coupled
