Receptor Mechanism 3 Flashcards
What are 3 different growth factor responses?
Tyrosine receptor kinase
JAK/STAT
Serine threonine receptor kinase
What happens in enzyme linked receptors?
When hormone binds to receptor,it leads to conformational change in either receptor or ligand or both
This allows dimerisation to occur which allows activation of subsequent pathways that these receptor control
What are enzyme linked receptors involved in?
Involved in regulation of cell growth, divisions, differentiation, survival + migration
Inappropriate activation is associated with disease particularly cancer
How do signalling proteins cross link receptor chain?
Ligand bind to receptor which causes dimerisation which brings receptor molecules close together
Close proximity allows enzyme activity that is present within intracellular part of receptor to come in close contact with substrate
Phosphorylation takes place, specific amino acid residues is phosphorylated
What is autoregulation?
The substrates of the enzyme are on the same molecule
Describe what occurs in tyrosine kinase activity?
Dimerisation brings 2 receptor molecules together allowing phosphorylation of specific tyrosine residues
Enzyme activity recognises specific tyrosine residues within adjacent neighbouring receptor molecules. It recognises tyrosine as surrounding amino acids forms a domain/motif that specific enzyme can recognise
Phosphotyrosine together with surrounding amino acids are recognised by SH2 domains of other proteins allowing them to bind + undergo activation
What is SH2 domain?
Sequence of amino acids form SH2 domain. These are recognised by other proteins. They are common structural theme within types of proteins