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Clinical Neurology > Receptor Classes: By NT > Flashcards

Receptor Classes: By NT Flashcards

1
Q

What two kinds of receptors are linked to ACh?

A
  • Muscarinic (m1,m2,m3,m4,m5)
  • Nicotinic (N1, N2)
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2
Q

Are the nicotinic ACh receptors excitatory or inhibitory? What kind of channel are they linked to?

A
  • N1 and N2 are both excitatory
  • Both linked to Sodium channels
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3
Q

Where are N1 receptors normally found? How about N2?

A

N1: at the neuromuscular junction

N2: in the brain

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4
Q

Which of the muscarinic receptors are excitatory? What second messengers are they linked to?

A
  • m1. m3, and m5
  • Incrased DAG and IP3
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5
Q

Which of the muscarinic ACh receptors are inhibitory? To which second messenger are they linked?

A

m2 and m4

linked to decreased cAMP

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6
Q

How many dopamine receptors are there?

A

D1, D2, D3, D4, D5

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7
Q

Which of the 5 dopamine receptors are excitatory? What second messenger are they linked to?

A

D1 and D5

-increased cAMP

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8
Q

Which of the 5 Dopamine receptors are inhibitory? To which second messenger are they linked?

A
  • the middle ones
  • D2, D3, D4
  • decreased cAMP
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9
Q

Which alpha adrenergic receptor is excitatory? To which second messenger is it linked?

A
  • Alpha1
  • Increased DAG
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10
Q

What NT do all of the adrenergic receptors have in common?

A

-Norepinepherine and Epinepherine

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11
Q

Which of the alpha adrenergics are inhibitory? What second messenger?

A

**-Alpha2 **

-decreased cAMP

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12
Q

Which of the ß adrenergic recetors are excitatory?

A

-ß1ß2ß3

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13
Q

What second messenger is linked to the excitation of -ß1 ß2 ß3 adrenergic receptors?

A

increased cAMP

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14
Q

Which seriotonin receptors are we concerned with?

A

5-HT1- 5-HT7

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15
Q

Whic of the serotonin receptors are inhibitory?

A

5HT1 and 5HT5

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16
Q

If 5-HT1 and 5-HT5 are inhibitory, to what second messenger are they linked?

A

-decreased cAMP

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17
Q

Which of the serotonin receptors are excitatory?

A

5-HT2

5-HT3

5-HT4

5-HT6

5-HT7

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18
Q

Which excitatory serotinin receptor is linked to increased DAG and IP3?

A

5HT<strong>2</strong>

19
Q

What is the excitatory serotonin receptor 5-HT3 linked to?

A

-ligand gated Sodium channels

20
Q

Which of the 7 5-HT receptors are linked to increased cAMP?

A

5-HT4

5-HT6

5-HT7

21
Q

Whaich of the Glutamate receptors are the only ones to be inhibitory?

A

mGluR2,3,4,6,7,8

*note that 5 is not included!

22
Q

What is the short list of excitatory glutamate receptors?

A
  • AMPA
  • Kainate
  • NDMA

mGluR1&5

23
Q

Which of the excitatory glutamate receptors is linked to ligand gated sodium channels?

A
  • AMPA
  • Kainate
  • NMDA: (also linked to Ca channels)
24
Q

What other ligand will the NMDA receptor respond to? What co-binding is required of this receptor?

A
  • Aspartate
  • co-binding of glycine required
25
Q

What are the excitatory glutamate receptors mGluR1&5 linked to?

A

-increased IP3 and DAG

26
Q

What second messenger are the inhibitory glutamate receptors (mGluR2,3,4,6,7,8)

A

-decreased cAMP

27
Q

Wha are the three kinds of GABA receptors?

A

GABAA

GABAB

GABAC

28
Q

What is the only effect that a GABA receptor can induce?

A

Inhibition

29
Q

Which GABA receptors are linked to Chloride gated channels?

A

GABAA

GABAC

30
Q

What kind of channel is GABAB linked to?

A

-Potassium

31
Q

How are glycine receptors similar to GABA receptors? Especially GABAA&C.

A
  • Linked to chloride channels
  • inhibitory
32
Q

How are glycine receptors different from GABA receptors?

A

-found primarily in the spinal cord

33
Q

How many histamine receptors are there?

A

4

H1, H2, H3, H4

34
Q

Which histamine receptors are excitatory?

35
Q

What are H1 and H2 excitatory histamine receptors linked to?

A

H1 is linked to increased DAG and IP3

H2 is linked to increased cAMP

36
Q

If H3 and H4 are inhibitory what second messenger are they ost likely linked to?

A

-decreased levels of cAMP

37
Q

What are the important adensine receptors?

A

A1, A2, A3

38
Q

Which of the adenosine receptors are inhibitory?

39
Q

Which of the adenosine receptors is excitatory?

40
Q

If A1 and A3 are inhibitory, which second messenger are they linked to? How about the excitatory adenosine receptor, A2?

A
  • A1 and A3= decrased cAMP
  • A2= increased cAMP
41
Q

O the two ATP type purigenic receptors, P2x and P2y, which is excitatory?

A

P2x

eXcitatory

42
Q

Which of the ATP type purigenic receptors is inhibitory? Which second messengeris it linked to?

A

P2y

increased DAG and IP3

43
Q

What channel is the excitatory ATP type purigenic P2x linked to?

A

-Sodium and Calcium

Clinical Neurology (8 decks)

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