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Clinical Neurology > Receptor Classes: By NT > Flashcards

Receptor Classes: By NT Flashcards

1
Q

What two kinds of receptors are linked to ACh?

A
  • Muscarinic (m1,m2,m3,m4,m5)
  • Nicotinic (N1, N2)
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2
Q

Are the nicotinic ACh receptors excitatory or inhibitory? What kind of channel are they linked to?

A
  • N1 and N2 are both excitatory
  • Both linked to Sodium channels
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3
Q

Where are N1 receptors normally found? How about N2?

A

N1: at the neuromuscular junction

N2: in the brain

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4
Q

Which of the muscarinic receptors are excitatory? What second messengers are they linked to?

A
  • m1. m3, and m5
  • Incrased DAG and IP3
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5
Q

Which of the muscarinic ACh receptors are inhibitory? To which second messenger are they linked?

A

m2 and m4

linked to decreased cAMP

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6
Q

How many dopamine receptors are there?

A

D1, D2, D3, D4, D5

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7
Q

Which of the 5 dopamine receptors are excitatory? What second messenger are they linked to?

A

D1 and D5

-increased cAMP

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8
Q

Which of the 5 Dopamine receptors are inhibitory? To which second messenger are they linked?

A
  • the middle ones
  • D2, D3, D4
  • decreased cAMP
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9
Q

Which alpha adrenergic receptor is excitatory? To which second messenger is it linked?

A
  • Alpha1
  • Increased DAG
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10
Q

What NT do all of the adrenergic receptors have in common?

A

-Norepinepherine and Epinepherine

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11
Q

Which of the alpha adrenergics are inhibitory? What second messenger?

A

**-Alpha2 **

-decreased cAMP

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12
Q

Which of the ß adrenergic recetors are excitatory?

A

-ß1ß2ß3

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13
Q

What second messenger is linked to the excitation of -ß1 ß2 ß3 adrenergic receptors?

A

increased cAMP

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14
Q

Which seriotonin receptors are we concerned with?

A

5-HT1- 5-HT7

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15
Q

Whic of the serotonin receptors are inhibitory?

A

5HT1 and 5HT5

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16
Q

If 5-HT1 and 5-HT5 are inhibitory, to what second messenger are they linked?

A

-decreased cAMP

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17
Q

Which of the serotonin receptors are excitatory?

A

5-HT2

5-HT3

5-HT4

5-HT6

5-HT7

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18
Q

Which excitatory serotinin receptor is linked to increased DAG and IP3?

A

5HT<strong>2</strong>

19
Q

What is the excitatory serotonin receptor 5-HT3 linked to?

A

-ligand gated Sodium channels

20
Q

Which of the 7 5-HT receptors are linked to increased cAMP?

A

5-HT4

5-HT6

5-HT7

21
Q

Whaich of the Glutamate receptors are the only ones to be inhibitory?

A

mGluR2,3,4,6,7,8

*note that 5 is not included!

22
Q

What is the short list of excitatory glutamate receptors?

A
  • AMPA
  • Kainate
  • NDMA

mGluR1&5

23
Q

Which of the excitatory glutamate receptors is linked to ligand gated sodium channels?

A
  • AMPA
  • Kainate
  • NMDA: (also linked to Ca channels)
24
Q

What other ligand will the NMDA receptor respond to? What co-binding is required of this receptor?

A
  • Aspartate
  • co-binding of glycine required
25
What are the excitatory glutamate receptors mGluR**1&5** linked to?
-increased **IP3** and **DAG**
26
What second messenger are the inhibitory glutamate receptors (mGluR2,3,4,6,7,8)
-decreased cAMP
27
Wha are the three kinds of GABA receptors?
GABAA GABAB GABAC
28
What is the only effect that a GABA receptor can induce?
Inhibition
29
Which GABA receptors are linked to Chloride gated channels?
GABAA GABAC
30
What kind of channel is GABAB linked to?
-Potassium
31
How are glycine receptors similar to GABA receptors? Especially GABAA&C.
- Linked to chloride channels - inhibitory
32
How are glycine receptors different from GABA receptors?
-found primarily in the spinal cord
33
How many histamine receptors are there?
4 H1, H2, H3, H4
34
Which histamine receptors are excitatory?
H1 and H2
35
What are H1 and H2 excitatory histamine receptors linked to?
H1 is linked to increased DAG and IP3 H2 is linked to increased cAMP
36
If H3 and H4 are inhibitory what second messenger are they ost likely linked to?
-decreased levels of cAMP
37
What are the important adensine receptors?
A1, A2, A3
38
Which of the adenosine receptors are inhibitory?
**A1** and **A3**
39
Which of the adenosine receptors is excitatory?
A2
40
If A1 and A3 are inhibitory, which second messenger are they linked to? How about the excitatory adenosine receptor, A2?
- A1 and A3= decrased cAMP - A2= increased cAMP
41
O the two ATP type purigenic receptors, P2x and P2y, which is excitatory?
P2x e***_X_***citatory
42
Which of the ATP type purigenic receptors is inhibitory? Which second messengeris it linked to?
P2y increased DAG and IP3
43
What channel is the excitatory ATP type purigenic P2x linked to?
-Sodium and Calcium
44

Clinical Neurology (8 decks)

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