Biochem- Role of Vitamin B12 in Brain Flashcards
1
Q
What 2 reactions require Vitamin B12 as a coenzyme?
A
- Methylmalonyl CoA Mutase reaction
- Conversion of Homocysteine to methionine (concomitat with THF conversion)
2
Q
What is the function of the methylmalonyl CoA mutase reaction?
A
It is a key step in the catabolism of some branched chain amino acids
3
Q
What kind of anemia is characterized by a B12 deficiency?
A
Megloblastic Anemia
4
Q
What causes the megloblastic part of megloblastic anemia?
A
-Folate is trapped as N-methyltetrahydrafolate and can not perform as required for normal purine synthesis
