Reasons for Association 1 Flashcards
Association
Link between two variables (exposure and outcome)
Causation
Relationship between cause and effect
Bradford-Hill’s criteria for assessing causation
Strength of association Consistency Specificity Temporality Biological gradient Biological plausibility Coherence Experiment Analogy
Strength of association
High association between risk and outcome, more likely to be causal
Consistency
Same in different populations, study designs, times etc
Specificity
One to one relationship (uncommon in reality)
Temporality
Exposure must precede outcome
Biological gradient
Change in intensity of exposure = change in risk of outcome
Biological plausibility
Potential bio mechanism to explain
Coherence
Relationship found agrees with current knowledge
Experiment
Removal of exposure alters frequency of outcome
Analogy
Relationship is in line with other established cause-effect relationships