reactions

Question 1

Hydroxylation of Lys

Answer 1

Question 2

Hydroxylation of Pro

Answer 2

Question 3

Synthesis of Purine nucleotides (de novo)

Glucose –> 5-phosphoribosyl-amine

Answer 3

Question 4

Synthesis of Purine nucleotides (de novo)

5-phosphoribosyl-amine –> IMP

Answer 4

Question 5

Synthesis of Purine nucleotides (de novo)

IMP –> GMP / AMP

Answer 5

Question 6

Synthesis of Purine nucleotides (de novo)

GMP / AMP –> GTP / ATP

Answer 6

Question 7

Degradation of Purine nucleotides

AMP -> Hypoxanthine

Answer 7

Question 8

Degradation of Purine nucleotides
Hypoxanthine –> Allantoine

Answer 8

Question 9

Degradation of Purine nucleotides

GMP –> Allontoine

Answer 9

Question 10

Synthesis of Pyrimidine nucleotides (de novo)

HCO3- –> Dihydrorotate

Answer 10

Question 11

Synthesis of Pyrimidine nucleotides (de novo)

Dihydroorotate –> UMP

Answer 11

Question 12

Synthesis of Pyrimidine nucleotides (de novo)

UMP –> CTP

Answer 12

Question 13

Degradation of pyrimidine nucleotides

Answer 13

Question 14

Resynthesis of Nucleotides (Salvage pathway)

In each nucleotide:

Answer 14

Question 15

Resynthesis of Nucleotides (Salvage pathway)

In Eucaryotes:

Answer 15

Question 16

Resynthesis of Nucleotides (Salvage pathway)

In prokaryotes:

Answer 16

Question 17

Synthesis of Deoxyribonucleotides:

Answer 17

Question 18

Degradation of Deoxyribonucleotides:

Answer 18

Differences compared to the degradation of ribonucleotides:

• Nucleoside phosphorylase releases deoxy-ribose-1-phosphate from deoxyribonucleosides
• At purine bases: no differences in steps of degradation
• At pyrimidine bases: differences in steps of degradation as follows:
• Deoxythymidine has one more methyl group, that is why instead of ureidopropioanate ureidoisobutyrate will be produces. The endproduct is instead of beta-alanine, beta-amino-isobutyrate