Reaction design Flashcards
What problems do you need to look at for experimental design?
Target product
Methodological
Process
What do you need to look at when looking at safety, cost and equipment?
COSSH
Risk assessments
Cost of chemicals
Availability of equipment
What do you need to think about when you need a certain product?
Look at the different ways of how you can make it
How would you decide on cost?
Look at the different ways you can make the product and compare the prices for each method, choosing the most cost effective one
What do you need to think about when you read the instructions?
Think about why for the steps
Why might ethanol be chosen as a solvent?
It solvates starting material
Moisture sensitive reactions - aprotic solvents
Water miscible solvent can affect aqueous work up
What are the two types of sequences in reactions?
Linear sequences
Convergent sequences
What is a linear sequence?
Multistep sequence, one pathway
What is a convergent sequence?
Different steps/pathways are combined to make the final product
How does the yield of a linear sequence compare to the yield of a convergent sequence?
The yield is worse in the linear sequence
What does a convergent sequence aim to do?
Aims to improve the efficiency of a multistep process
What do you quote for a convergent sequence?
The longest linear sequence
What do you need to think about when you choose glassware?
Reaction scale
Never fill more than 1/2
Length of stirring time
If there is heating or cooling required
What three things do you need to think about when you design an air-sensitive reaction?
Dry conditions
Nitrogen/argon conditions
Cooling conditions/temperature
What does mass spec look at?
Molecular weight
