RCT

Question 1

What is RCT

Answer 1

planned experiment in humans,, designed to assess efficacy of treatment/intervention
ethically justified if no existing evidence that intervention being tested will be superior to existing treatment or effectivee at all

Question 2

What are RCTs used to evaluate

Answer 2

method of: diagnosis, organising care, screening for disease, disease prevention, healthcare policies

Question 3

What features of RCT helps protect against bias

Answer 3

randomisation, blinding, ITT analysis

Question 4

How to decide what types of controls to use in RCT

Answer 4

Placebo-if benefit from treatment not established

Control-if benefit from treatment established

Question 5

How to calculate absolute risk reduction

Answer 5

Risk in control in proportion with outcome-risk in intervention in proportion with outcome

Question 6

How to calculate relative risk reduction

Answer 6

(Risk in control-risk in intervention))/risk in control

Question 7

What is Number needed to treat and how do you calculate it

Answer 7

Number of patients who would have to receive treatment of interest in order to prevent adverse event in one patient
NNT=1/ARR