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Solids 2 > RCC 2 > Flashcards

RCC 2 Flashcards

1
Q

Papillary RCC is associated with what mutation?

A

MET

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2
Q

Papillary RCC is associated with what mutation?

A

Met

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3
Q

Stage I RCC is:

A

T1N0M0
Less than 7 cm

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4
Q

Stage II RCC is:

A

T2N0M0
More than 7 cm, confined to kidney

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5
Q

Stage III RCC is:

A

T11-2, N1 or T3 N0-1
T3 means extending outside kidney

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6
Q

What is T4 RCC?

A

Invasion beyond Gerota’s fascia

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7
Q

T4N0 is what stage RCC?

A

IV

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8
Q

What 5 things make up the IMDC prognostic model?

A

KPS <80
Anemia
HyperCa
Thrombocytosis
Leukocytosis
Diagnosis to treatment <1 year

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9
Q

Treatment for Stage 1-2 RCC?

A

Nephrectomy (partial or radical)
Partial is preferred in Stage I

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10
Q

Stage 3 RCC treatment

A

Radical Nephrectomy, adjuvant Pembro for high risk

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11
Q

Whwat patients are eligible for adjuvant Pembro? (5)

A

pT2, grade 4 or sarcomatoid
pT3, any grade
pT4, any grade
Any N+
Also patient with complete resection of oligometastatic disease

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12
Q

Which patients with metastatic disease should you consider an upfront nephrectomy?

A

Minimal metastatic burden with easily resectable primary

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13
Q

4 preferred 1L treatment options for mRCC?

A

Ipi/Nivo
Cabo/Nivo
Pembro/Len
Axi/Pembro

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14
Q

Ipi/Nivo is not good for what subpopulation of patients with mRCC?

A

Bone mets

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15
Q

What is the survival benefit for VEGF TKI + ICI in favorable risk mRCC?

A

No OS benefit, but PFS benefit

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16
Q

2L options for mRCC in those with prior IO therapy (5)

A

Axitinib
Belzutifan
Cabo
Everolimus + L:envatinib

17
Q

Indication for Tivozanib

A

3L mRCC

18
Q

3 treatment options for 1L m non-ccRCC

A

Pem/Len
Cabo/Nivo
Cabo

19
Q

VHL disease causes what clinical features?

A

RCC
Pancreatic NET
Renal cysts
Hemangioblastomas (retinal, cerebellar, spinal)

20
Q

Treatment for VHL-associated RCC?

A

Belzutifan

21
Q

Preferred treatment for renal angiomyolipomas associated with TSC

A

Everolimus

22
Q

Mutation associated with hereditary papillary RCC

A

MET

23
Q

Mutation in Birt Hogg Dube syndrome

A

FLCN

24
Q

RCC plus spontaneous pneumothorax should make you think of what syndrome?

A

Birt Hogg Dube syndrome

25
Q

What are 3 1L monotherapy options for favorable risk mRCC?

A

Pazopanib
Sunitinib
Axitinib

26
Q

What are 3 1L monotherapy options for poor/intermediate risk RCC?

A

Cabozantinib (best monotherapy)
Pazopanib
Sunitinib

27
Q

2L options in mRCC in ICI-naive patients (7)

A

Axi Pembro
Cabo
Cabo Nivo
Ipi Nivo
Everolimus Len
Pembro Len
Nivo

Solids 2 (10 decks)

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