Pancreatic 2 Flashcards

1
Q

Which patients with pancreatic cancer should get germline genetic testing?

A

Everyone

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2
Q

Who are borderline resectable patients?

A

Stage II/III
Abutment of an artery <180 degrees

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3
Q

What is considered locally advanced pancreatic cancer?

A

T4Nx

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4
Q

What is considered resectable pancreatic cancer?

A

T1-3, N0-1

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5
Q

Standard of care treatment paradigm for resectable pancreatic cancer?

A

Up front surgery then adjuvant chemotherapy for 6 months (Gem, Gem-Cape, mFOLFIRINOX, or Gem-Nab paclitaxel)

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6
Q

Adjuvant therapy for resectable pancreatic cancer in an elderly patient? (2)

A

Gemcitabine or Gem+cape

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7
Q

Adjuvant therapy for resectable pancreatic cancer in a fit patient with ECOG 0 without comorbidities?

A

FOLFIRINOX (Gem + 5-FU, Gem+Cape also)

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8
Q

Who should get adjuvant chemoradiation in resectable pancreatic cancer?

A

R1 resection, but should get 4-6 months of chemotherapy first

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9
Q

1st line metastatic pancreatic cancer (2)

A

Gem-Nab
FOLFIRINOX (KPS >70%)

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10
Q

FOLFIRINOX should be reserved for which PC patients in the first line metastatic setting?

A

KPS >70%

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11
Q

Indication for olaparib in pancreatic cancer?

A

Maintenance for patients with BRCA1 or 2 mutation with platinum sensitive disease in metastatic setting.

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12
Q

Most common KRAS mutation in PC?

A

G12D

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13
Q

Pembro indication in PC

A

MSI-H, generally in 2nd line
(Or TMB >10)

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14
Q

Met PC treatment option with NTRK fusion? (2)

A

Entrectinib
Larotrectinib

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15
Q

Treatment option for mPC with NRG fusion

A

Afatinib

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16
Q

Treatment paradigm for borderline resectable PC?

A

Neoadjuvant chemotherapy +/- chemoradiation, and surgery if it becomes resectable

17
Q

Best 2L option for patients with mPC that progress on Gem-Nab?

A

5-FU + Liposomal Irinotecan

18
Q

Which patients with resectable pancreatic cancer should receive neoadjuvant chemotherapy+/- chemoRT instead of up front surgery?

A

High risk features:
-Markedly elevated Ca 19-9
-Large tumors
-Large regional LNs
-Excessive weight loss
-Extreme pain

19
Q

How does NALIRIFOX compare to Gem-Nab in 1L mPC?

A

NALIRIFOX has improved OS and PFS. Don’t know how it compared to mFOLFIRINOX though