Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Solids 2 > Pancreatic 2 > Flashcards

Pancreatic 2 Flashcards

1
Q

Which patients with pancreatic cancer should get germline genetic testing?

A

Everyone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Who are borderline resectable patients?

A

Stage II/III
Abutment of an artery <180 degrees

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is considered locally advanced pancreatic cancer?

A

T4Nx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is considered resectable pancreatic cancer?

A

T1-3, N0-1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Standard of care treatment paradigm for resectable pancreatic cancer?

A

Up front surgery then adjuvant chemotherapy for 6 months (Gem, Gem-Cape, mFOLFIRINOX, or Gem-Nab paclitaxel)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Adjuvant therapy for resectable pancreatic cancer in an elderly patient? (2)

A

Gemcitabine or Gem+cape

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Adjuvant therapy for resectable pancreatic cancer in a fit patient with ECOG 0 without comorbidities?

A

FOLFIRINOX (Gem + 5-FU, Gem+Cape also)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Who should get adjuvant chemoradiation in resectable pancreatic cancer?

A

R1 resection, but should get 4-6 months of chemotherapy first

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

1st line metastatic pancreatic cancer (2)

A

Gem-Nab
FOLFIRINOX (KPS >70%)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

FOLFIRINOX should be reserved for which PC patients in the first line metastatic setting?

A

KPS >70%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Indication for olaparib in pancreatic cancer?

A

Maintenance for patients with BRCA1 or 2 mutation with platinum sensitive disease in metastatic setting.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Most common KRAS mutation in PC?

A

G12D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Pembro indication in PC

A

MSI-H, generally in 2nd line
(Or TMB >10)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Met PC treatment option with NTRK fusion? (2)

A

Entrectinib
Larotrectinib

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Treatment option for mPC with NRG fusion

A

Afatinib

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Treatment paradigm for borderline resectable PC?

A

Neoadjuvant chemotherapy +/- chemoradiation, and surgery if it becomes resectable

17
Q

Best 2L option for patients with mPC that progress on Gem-Nab?

A

5-FU + Liposomal Irinotecan

18
Q

Which patients with resectable pancreatic cancer should receive neoadjuvant chemotherapy+/- chemoRT instead of up front surgery?

A

High risk features:
-Markedly elevated Ca 19-9
-Large tumors
-Large regional LNs
-Excessive weight loss
-Extreme pain

19
Q

How does NALIRIFOX compare to Gem-Nab in 1L mPC?

A

NALIRIFOX has improved OS and PFS. Don’t know how it compared to mFOLFIRINOX though

Solids 2 (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions