RBCs And WBCs

Question 1

Predominant WBC in adults

Answer 1

Neutrophils

Question 2

Neutrophils and monocytes are direct descendants of a common progenitor, known as?

Answer 2

GMP

Question 3

Majors stimulatory cytokine for neutrophil production 

Answer 3

G-CSF

Question 4

What is the half-life of neutrophils in the blood?

Answer 4

7 hours

Question 5

Able to trap and kill gram-positive and gram-negative bacteria, as well as fungi?

Answer 5

NETs (Neutrophil Extracellular Traps)

Question 6

An enzyme that exhibits bactericidal, fungicidal and viricidal properties

Answer 6

MPO

Question 7

Lysozyme is also known as

Answer 7

Muramidase

Question 8

And iron-binding protein that competes with bacteria for iron

Answer 8

Lactoferrin

Question 9

The most specific cytokines for eosinophil lineage

Answer 9

IL-5

Question 10

Circuiting half life of eosinophils

Answer 10

18 hours

Question 11

Survival time of eosinophils in human tissues ranges from

Answer 11

2 to 5 days

Question 12

This happens when extracellular intact granules are deposited during cell lysis

Answer 12

Cytolisis

Question 13

A method of eosinophil degranulation, where secretary vehicles removes specific proteins from the secondary granules. These vesicles then travel to the plasma membrane and infused to empty specific proteins into the extracellular space. 

Answer 13

Piecemeal degranulation

Question 14

Color of Charcot-Leyden crystal in: Hematoxylin, Eosin and Trichrome stain

Answer 14

Hematoxylin- Black
Eosin- Red
Trichrome stain- Purplish-red

Question 15

Life span of basophils

Answer 15

60 hours

Question 16

A dye that can bind with acid mucopolysaccharides in blood cells to form metachromatic complexes

Answer 16

Toluidine blue

Question 17

Histochemically defined as a reaction product color that is considerably different from the color of the dye itself

Answer 17

Metachromasia

Question 18

An enzyme needed to breakdown lipids

Answer 18

Sphingomyelinase

Question 19

Rare autosomal recessive
Deficiency of sphingomyelinase
Splenomegaly and hepatomegaly
Characteristic cells: Pick’s cells
A MAC whose cytoplasm is swollen by many small lipid droplets

Answer 19

Niemann-Pick Disease

Question 20

Niemann-Pick Disease which is fatal by 3 yrs of age, is most commonly seen in?

Answer 20

Ashkenazi Jews

Question 21

Most common lipidoses, Aut. Recess.; defect OR deficiency in the catabolic enzyme B-glucerebrosidase

Answer 21

Gaucher Disease

Question 22

Appearance of Gaucher cell

Answer 22

Crumpled tissue paper or onion skin

Question 23

A rare hereditary condition characterized by normal granulocyte production. Nevertheless, there is impaired released into the blood leading to neutropenia. 

Answer 23

Myelokathexis

Question 24

Most common genetic disorder of WBCs; it is the failure of the neutrophil nucleus the segment
“Pince-nez” or “spectacle” form neutrophil nucleus
Autosomal Dominant

Answer 24

Pelger-Huet Anomaly aka True/Congenital PHA

Question 25

This is an inner nuclear membrane protein; place a major role in leukocyte nuclear shape changes that occur during normal maturation

Answer 25

Lamin beta-receptor 

Question 26

True or false. There is normal granulation in through PHA 

Answer 26

True

Question 27

ME ratio of leukemia

Answer 27

10:1

Question 28

Type of anemia usually seen in cases of acute leukemia

Answer 28

Normo normo

Question 29

Most common form of childhood leukemia

Answer 29

Acute Lymphocytic Leukemia

Question 30

Peroxidase stain rules out what type of leukemia?

Answer 30

Acute Lymphocytic Leukemia (ALL)

Question 31

Most sensitive stain for granulocytic precursors

Answer 31

Sudan Black B (SBB)

Question 32

Basic unit of Radiation

Answer 32

Photon

Question 33

Part of the platelet that ultimately dileanates individual platelets during thrombocytopoeisis

Answer 33

Demarcation System

Question 34

An unique phospholipid found in the inner cytoplasmic layer of the platelets which flips to the outer surface upon activation, and is the charge phospholipid surface on which 2 coagulation pathway complexes assemble 

Answer 34

Phosphatidylserine

Question 35

What are the two coagulation passed away complexes that assembles at the phosphatidylserine surface?

Answer 35

TENASE complex and PROTHROMBINASE complex 

Question 36

It is the cellular ultrastructural component, unique only to the platelets

Answer 36

Glycocalyx

Question 37

A molecule that binds to another molecule (especially the reference to a small molecule that specifically binds to the larger molecule)

Answer 37

Ligand

Question 38

What does CAM stand for?

Answer 38

Cell Adhesion Molecule

Question 39

What are the Ligands of GPIa/IIa? 

Answer 39

Collagen Vitronectin Laminin Fibronectin

Question 40

Deficiency of Factor V

Answer 40

Owren's Disease/ Parahemophilia

Question 41

First coagulation factor to be affected by warfarin therapy

Answer 41

Factor VII