RBC DISORDERS Flashcards
1
Q
Point mutation in which gene
A
Beta globin gene
2
Q
_______ acid is replaced by ______ acid in 6th position
A
Glutamic acid
Valine
causes aggregation of Hb
3
Q
Size of sickle cells
A
4
Q
Skull x ray findings
A
Crew cut d/t marrow expansion from erythropoies
5
Q
RBC findings
A
Crescent shaped
6
Q
Complications
A
Aplastic crisis due to PVB19
Autosplenectomy HJ bodies
Splenic infarct sequestration crisis
Painful vaso occlusive crisis dactylitid priapism acutr chest syndrome
CXR CHEST INFILTRATES
Avascular necrosis
Stroke
Hemauria ( suckling in renal medulla > renal papillary necrosis)
7
Q
IOC
A
HPLC
HB EP - ⬆️ HbF HbS
8
Q
Treatment
A
Hydroxyurea
Stem cell transplant
