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HEMA LEC > RBC anomalies > Flashcards

RBC anomalies Flashcards

1
Q

It refers to erythrocytes with normal amount of hemoglobin

A

Normochromic cell

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2
Q

Refers to erythrocytes where the central light area is larger and paler than the normal which MCH and MCHC are decreased, it is also often associated with microcytosis

A

Hypochromic cell

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3
Q

Red cells which have an increased hemoglobin content and wherein the central light area is smaller than the normal

A

Hyperchromic cell

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4
Q

This condition wherein the red cell are stained w/ various shades of blue w/ tinges of pink due to affinity of hb to acid and affinity of RNA to basic dye, it also indicates reticulocytosis

A

POLYCHROMATOPHILIA/POLYCHROMASIA/DIFFUSE BASOPHILIA

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5
Q

Condition where the red cell appear as pale, it has two possible causes which is dec. Hb concentration and abnormal thinness of the cells

IDA, SIDEROBLASTIC ANEMIA, THALASSEMIA

A

Hypochromasia

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6
Q

Condition where red cell are deeply stained into abnormal thickness of cell due to macrocytosis sherocytosis and megaloblastic anemia

A

Hyperchromasia

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7
Q

Condition where the red cells vary in both macrocytes and microcytes coexist in the same smear

A

Anisocytosis

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8
Q

Normal size in diameter of redcells

A

6-8um in diameter

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9
Q

Cells larger than normal greater than 8um in size round in shape mcv>100 fl

A

Macrocyte

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10
Q

What disease macrocyte detect?

A

Abnormal nuclear maturation
But normal cytoplasmic maturation

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11
Q

Associated disease in macrocyte

A

Non megaloblastic anemia
Myelodysplastic syndrome
Chronic liver disease
Bm failure
Reticulocytosis

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12
Q

Cells which is less than 6um in size

A

Microcytosis

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13
Q

Microcytosis is found in

A

IDA
THALASSEMIA
HEMOLYTIC ANEMIAHB E DISEASE
INFLAMMATION
CHRONIC POST HEMORRHAGIC ANEMIA
SIDEROBLASTIC ANEMIA

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14
Q

A large oval shaped red cell which is 9-12 um

A

Megalocyte

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15
Q

Megalocyte is found in

A

Megaloblastic anemia like pernicious anemia
Anemia
VIT B12 DEFICIENCY
D. LATUM INFECTION

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16
Q

Redcells exhibit variation in shape

A

Poikilocytosis

17
Q

A normal cell with a biconcave diskshape with increased surface of volume surface

A

Discocyte

18
Q

It is a small dense rbc with a few irregularly spaced projection of varying length

A

Acanthocyte(spur cell)

19
Q

Acanthocyte can detect

A

Abnormal membrane defect cause by an increase shingomyelin and dec cholesterol and phospholipid

20
Q

Associated disease in acanthocyte

A

Neuroacanthocytosis
Severe liver disease

21
Q

Cell membrane is folded

A

Biscuit cell (folded RBC)

22
Q

Cell assumes a pocket book roll appearance or biscuit shape, it also associated with HBSC & HBCC DISEASE

A

Biscuit cell

23
Q

Abnormal lipid content of the membrane which cell irregularly spaced blunt processes resemble crenated RBC

A

Burr cell

24
Q

Associated disease with burr cell

A

Uremia
MAHA
LIVER DISEASE
DIC
TIP
PK

25
Q

It can detect g6p def resulting to accumulation of Heinz bodies, cell with eccentric vacuoles due to the plucked out of heinz bodies

A

Blister cell(bite cell)

26
Q

Atp deficiency due to prolonged storage of anticoagulated blood

Pathologically due to abnormal lipid content of the membrane

A

Crenated cells/echinocytes/Sea-urchin cells

27
Q

Associated disease in crenated cells

A

Seen in uremia
bleeding
Ulcers
Gastric carcinoma
Hepatitis
Cirrhosis

28
Q

It is a def. In cholesterol phospholipid in the membrane def in lecithin cholesterol acyl transferase(LCAT)

Cell with central area of hb surrounded by colorless area and a peripheral ring

A

Codocytes/targetcell/bull’s eye cell/Mexican hat

29
Q

Disease associated with codocytes

A

THALASSEMIA
LIVER DISEASE
HEMOLYTIC ANEMIA
HEMOGLOBIN SS
LCAT DEF

30
Q

Abnormal maturation squeezing and fragmentation during splenic passage where cell appear in the shape of a teardrop or pear with a single short or long protrusion

A

Teardrop cell (Dacrocyte)

31
Q

Associated disease with teardrop cell

A

HA, MA, MMM

32
Q

A membrane due to defective spectrin def in band protein 4.1

Hb appear to be concentrated at the two ends of the cell leaving a nirmal central area of pallor, and life span is shortened

A

Elliptocytes/ovalocytes

33
Q

Elliptocytes/ovalocytes is usually found in

A

megaloblastic anemia
Hypochromic anemia
Hederitary ovalocytosis

34
Q

Small round dense cell w/c lacks the central palor area usually microcytic and sphere shaped and primary detect spectrin def, secondary defective interaction of spectrin w/ other skeletal protein

A

Spherocyte

35
Q

Associated disease in spherocyte

A

HS
CHRONIC LYMPHOCYTE LEUKEMIA
IMMUNE HEMOLYTIC ANEMIA DUE TO ABO INCOMPATIBILITY
EXTENSIVE BURN
HEREDITARY SPHEROCYTOSIS

36
Q

Is a crescent shape due to abnormal aggregation of hbS which gives a tendency for the cell to assume sickle shape

A

Sickle cell/drepanocytes

37
Q

Cell fragmentation due to the trauma caused by physical and mechanical agents, it is irregularly contracted cell, fragmented cell

A

Schistocytes

38
Q

It is characterized by an elongated or sot like area of central pallor

It is caused by osmtic changes due to cation imbalance (Na, k)

A

Stomato cyte/mouth cells

HEMA LEC (3 decks)

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