Hemoglobin

Question 1

how many ml of oxygen can a One gram of Hgb can carry?

Answer 1

1.34ml

Question 2

Function of the Hgb.

Answer 2

•Transport oxygen from the lungs
to the tissue and carbon dioxide
from the tissue.
•Acid –base balance regulation

Question 3

Hemoglobin H

Answer 3

Abnormal hemoglobin occur in some case of alpha thalassemia. Composed of 4 beta globin chain produced in response to severe shortage of alpha chain

Question 4

One of most common beta chain hemoglobin variant in the world. People who have homozygous for Hb E have 2 copies of (beta epsilon) generally have mild hemolytic anemia, microcytic red blood cells and large enlargement of spleen. Single copy of hemoglobin E does not cause symptoms unless it is combined with another mutation, such as 1 for beta thalassemia trait.

Answer 4

Hemoglobin E (Egal)

Question 5

Temperature shift to the left

Answer 5

Decrease

Question 6

pH shift to the right

Answer 6

Decrease

Question 7

Organic phosphate shift to the left

Answer 7

Decrease

Question 8

Number of amino acid- 141

Answer 8

Alpha and Zeta

Question 9

Number of Amino Acid- 146

Answer 9

Beta, Gamma A, Gamma B, Delta, Epsilon

Question 10

Results from binding of carbon monoxide to heme iron. Hb can combine with carbon monoxide with affinity 200 times greater than Oxygen.
Carbon monoxide termed as silent killer for its colorless gas, odor and patient becomes easily hypoxic.

Answer 10

Carboxyhemoglobin

Question 11

Affinity of 200-240 time greater than Oxygen

Answer 11

Carboxyhemoglobin

Question 12

Treatment= Intravenous methylene blue- %

Answer 12

Methemoglobin

Question 13

Binding and releasing of hemoglobin to oxygen, oxygen to pH

Answer 13

Affinity

Question 14

(SgaVal) primary hemoglobin in people with sickle cell disease. Those with Hb S disease have 2 abnormal beta chain and 2 normal alpha chain.
Cause of red blood cell to deform and assume sickle shape when expose to decrease amount of oxygen.

Answer 14

Hemoglobin S

Question 15

is replaced by valine in the 6th position of beta chain

Answer 15

Glutamic acid

Question 16

(FAG) major hemoglobin of fetus and newborns. Compose of 2 alpha 2 gamma. Produce 4 months after conception.

Answer 16

Fetal hemoglobin

Question 17

Synthesis of globin

Answer 17

occurs in ribosomes using messenger RNA that is translated into polypeptide chain. Synthesis of globin is controlled in the chromosomes of alpha and beta.

Question 18

Normal adult hemoglobin. 95 to 97% of hemoglobin in normal adults produced after 1 year onwards. Composed of 2 alpha (141 AA) and 2 beta chain (146 AA)

Answer 18

Hemoglobin A or A1

Question 19

1 heme

Answer 19

1 mole of oxygen

Question 20

1 hbg

Answer 20

4 moles of oxygen

Question 21

1 gram of hemoglobin

Answer 21

Carry 1.34 of oxygen

Question 22

Heme synthesis

Answer 22

Produce complete heme, 8 steps involved 4 enzymes in mitochondria and 4 enzyme in cytoplasm

Question 23

Heme

Answer 23

Occurs in mitochondria and cytoplasm of bone marrow

Question 24

Sulfhemoglobin

Answer 24

Form by irreversible oxidation of Hb of certain drugs and chemical.
A. Sulfonamides
B. Phenacitin
C. Acetinalde
Form by addition of hydrogen sulfide to hgb has a greenish pigment.
If sulfhemoglobin reaches critical level in blood it imparts mauve lavender.