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1
Q

Extravascular Hemolytic anemia

A

Anemia splenomeg jaundixe

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2
Q

Anemia hb hburia hemosiderunria jaundice

A

Intravascular Hemolytic anemia

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3
Q

Hemolytic anemia

A

Normonlastss, reticulocytosis, cholelith

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4
Q

Morphology of Hemolytic anemia

A

Normochtic, normochromoic

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5
Q

Genetic of hereditary apherocytosis

A

Ad

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6
Q

Spheorid cell, less deformable

A

hereditary apherocytosis

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7
Q

Mutation of ankyrin band 3 /

Spectrin

A

hereditary apherocytosis

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8
Q

Congestion of cords of billroth inc # of cords of billroth, inc phagocytes in spleen

A

hereditary apherocytosis

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9
Q

Due to parvovirus b19

A

hereditary apherocytosis

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10
Q

Due to env mononuc

A

hereditary apherocytosis

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11
Q

Small dark nuclear remants preaent n rbc os asplenic pts

A

Howell jolly bodies in splenomegaly

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12
Q

Xnlinked recessive disorder, reduce ability rbc to protect themselves agaisnt oxidative ij and lead to hemolysis

A

G6pd

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13
Q

What infn causeG6pd

A

Biral hepa, pneumonia, typhoid fevery

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14
Q

Drugs cause G6pd

A

Antimalarial, sulfa, nitrofurantoin

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15
Q

Protective against malaria

A

G6pd

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16
Q

Rate lim of pp

A

G6pd

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17
Q

Reduce nadp to nadph

A

G6pd

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18
Q

Membrane bound precipitates in denatured globin chains

A

Heinz bodies

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19
Q

Rbcs wt damaged membranes

A

Bkte cells

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20
Q

Acute intravasculae hemolysis wrhin 2-3 days- anemia, hbnuria, hbnemia

A

G6pd

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21
Q

Recovery helarded by reticuloscytosis

A

G6pd

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22
Q

Autosomal recessive hemoglobinopathy, african

A

Sickle cell anemia

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23
Q

Small nuclear remannts in rbc dt asplenia

A

Howell jolly

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24
Q

Trapping of sickles cell leads to splenic fibrosis

A

Autosplenectomy

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25
Q

Dehydrated rbcs wt bulls eye appearance

A

Trget cells

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26
Q

Rbc like curved blades

A

Sickled cellt

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27
Q

Episode of hupoxid inj and infarct

A

Vasooclusive crisis

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28
Q

Massive entrapment of sickles crll leads to rapud splenic enlargemnt hypovolemia

A

Sequestration crisi

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29
Q

Infection of rbc progenitors by parvo b19

A

aastoc anemia

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30
Q

Inability to con urine

A

Hypostjenuria

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31
Q

Inc susceptibility wr encapsulated organis

A

Sickle cell

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32
Q

Prom cheeckbones, crewvut skull appearnce

A

Sickle cell

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33
Q

Best initial dx for sickle cell

A

Pbs

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34
Q

Dx gold standard

A

hb electropheresis

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35
Q

Doc fir sickle crll ania

A

Hydroxyurea

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36
Q

Chipmunk facies, crew cut skull, splenomegaly, hemochromotasosi

A

Thalassemia

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37
Q

Codixytes

A

Thalassemia

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38
Q

Basophilic stippling

A

Thalassemia

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39
Q

Microcytic hupochrmoic

A

Thalassemia

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40
Q

1 tx for hemochromatosi

A

Phleb

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41
Q

Id nonresponsive

A

chelation wt deferoxamine

42
Q

Intravasculat hemolysis dt inc complement mediated rbc lysis

43
Q

Dx of pnh

A

Flow cytometry

44
Q

Low rbc during sleep

45
Q

Rm temp death of rbc

A

Warma agglutinin

46
Q

Death rbc by col

A

Cold aglutinin seen wt mycoplasma pn

47
Q

Ig cold hot

48
Q

Igg ti bloodw

A

Direct coombs

49
Q

Normal rbc to pts serum

A

Indirect coombs

50
Q

Rbc damaged thru passing narrowed vessels

A

Microangiopathic

51
Q

Microangiopathic seen in

A

Dic, ttp, hus, sle

52
Q

Morpho microangiopathic

A

Sccjistocytes, blur cell

53
Q

Impairment if dna synt leads to distinctive morphologic chanes

A

Megaloblastic anemia

54
Q

Morph of megaloblastic

A

Macoovalocyte if rbc, hypersegmented neutr

55
Q

Diff deficiency if vit b12 folate👻

A

Neurologic sx🎅

56
Q

Parasituc infxn of megaloblastuc

57
Q

Tx 🎣

58
Q

Caused by autoimmune gastritis and fec if

A

Pernicious anemia

59
Q

Atrophy of fundic glands, intestinaluziation

A

Pernicious anemia

60
Q

Shiny glazed beefy tongue

A

Pernicious anemia

61
Q

Demyelination of dirsala nd lat tracts of sc

A

Pernicious anemia

62
Q

Stage 1 scholling

63
Q

Schilling stage 2

64
Q

Low stage 1 nirmal stage 2

A

Pernicious anemia

65
Q

Parasitic infxn lead to microcytic hypochromic anemia

66
Q

Doc for hookworlms

A

Albendazole

67
Q

Morpho ida

A

Disappearance if stainable iron fr macrophages in marrow in prissiona blu

68
Q

S/sx o ia

A

Pica, plummer vinson syndrome ( esophageal webs, atrophic glossitis

69
Q

Stimulate hepcidin

70
Q

Reduce iron transerfr stirage pool to bone marriw

71
Q

Syndrome of chronic primary hematopoietic failure and atendant pancytopenia

A

Aplastic anemia

72
Q

Ab cause idiosyncratzic aplastic anemia

73
Q

Chemical causes aplastic anemia

74
Q

Morph aplastic anemia

A

Hypocellular bm wt fat cells dry tap

75
Q

Diff aa and myelodysplastic anemia

A

Mds has hypercellular

76
Q

Selective hypoplasia of marriw erythroid. Normal granulpoiesis and thrombopoiesus

A

Pure red cella palsia

77
Q

Plt less than 100,00

A

Thrombocytopeniat

78
Q

Spont blleed

79
Q

Caused bu antipaletelet antibidy

80
Q

Sec to viral infxn

81
Q

Morfo itp

A

Congestionnof sinusoids enlargement of follicles, megathrombocytes

82
Q

Mist feared complication of itp

A

Intracranial bleed

83
Q

Tx ito

A

Glucocorticoid, splenectomy, rituxab

84
Q

Spectrum of ttp and hus

A

Thrombotic microangiopathis

85
Q

Pentad if ttp

A

Fever, thrombocytopenia, mha, neuro def, renal failure

86
Q

Triad hus

A

Microangiopathic hemolytic anemia, thrombocytopenia, renal failure

87
Q

Def of adamst13

88
Q

Causes by shiga like toxin ehec

89
Q

Inc bleeding time

A

Platelet dysfxn

90
Q

Defective plt adhesion

A

Bernard soulier

91
Q

Dec gp 2b-3a

92
Q

Sx of bleeding + normal platelet

93
Q

Tx of vwd

A

Desmoprrssin

94
Q

Most common life threatening assoc wt life threatening bleeding

A

Hemophilia a

95
Q

Chrisas disease

A

Heophilia b

96
Q

Acute, subacute or chronic thrombohemorrhaguc disorder

97
Q

Causes of dic

A

Sepsis, trauma, obstetric comp, pancreetitis, malig, mephrotic synd, transfusion

98
Q

Fibrin thrombi lead to massive adrenal hemorrhages

A

Water friderichsen synd

99
Q

Post partum pituitary necrosi

A

Sheehan synd

100
Q

Widespread microtjrombi onnplacenta

A

Toxemia n preg

101
Q

Tests for dic

A

Fibrinogen, plt, pt/ptt, fibrin, degradation products

102
Q

Premature destruction of rbc, elev erythropoeitin level. Accumulation of hb pro

A

Hemolytic anemia

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