Rbc Flashcards
Extravascular Hemolytic anemia
Anemia splenomeg jaundixe
Anemia hb hburia hemosiderunria jaundice
Intravascular Hemolytic anemia
Hemolytic anemia
Normonlastss, reticulocytosis, cholelith
Morphology of Hemolytic anemia
Normochtic, normochromoic
Genetic of hereditary apherocytosis
Ad
Spheorid cell, less deformable
hereditary apherocytosis
Mutation of ankyrin band 3 /
Spectrin
hereditary apherocytosis
Congestion of cords of billroth inc # of cords of billroth, inc phagocytes in spleen
hereditary apherocytosis
Due to parvovirus b19
hereditary apherocytosis
Due to env mononuc
hereditary apherocytosis
Small dark nuclear remants preaent n rbc os asplenic pts
Howell jolly bodies in splenomegaly
Xnlinked recessive disorder, reduce ability rbc to protect themselves agaisnt oxidative ij and lead to hemolysis
G6pd
What infn causeG6pd
Biral hepa, pneumonia, typhoid fevery
Drugs cause G6pd
Antimalarial, sulfa, nitrofurantoin
Protective against malaria
G6pd
Rate lim of pp
G6pd
Reduce nadp to nadph
G6pd
Membrane bound precipitates in denatured globin chains
Heinz bodies
Rbcs wt damaged membranes
Bkte cells
Acute intravasculae hemolysis wrhin 2-3 days- anemia, hbnuria, hbnemia
G6pd
Recovery helarded by reticuloscytosis
G6pd
Autosomal recessive hemoglobinopathy, african
Sickle cell anemia
Small nuclear remannts in rbc dt asplenia
Howell jolly
Trapping of sickles cell leads to splenic fibrosis
Autosplenectomy
Dehydrated rbcs wt bulls eye appearance
Trget cells
Rbc like curved blades
Sickled cellt
Episode of hupoxid inj and infarct
Vasooclusive crisis
Massive entrapment of sickles crll leads to rapud splenic enlargemnt hypovolemia
Sequestration crisi
Infection of rbc progenitors by parvo b19
aastoc anemia
Inability to con urine
Hypostjenuria
Inc susceptibility wr encapsulated organis
Sickle cell
Prom cheeckbones, crewvut skull appearnce
Sickle cell
Best initial dx for sickle cell
Pbs
Dx gold standard
hb electropheresis
Doc fir sickle crll ania
Hydroxyurea
Chipmunk facies, crew cut skull, splenomegaly, hemochromotasosi
Thalassemia
Codixytes
Thalassemia
Basophilic stippling
Thalassemia
Microcytic hupochrmoic
Thalassemia
1 tx for hemochromatosi
Phleb