Rbc Flashcards

1
Q

Extravascular Hemolytic anemia

A

Anemia splenomeg jaundixe

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Anemia hb hburia hemosiderunria jaundice

A

Intravascular Hemolytic anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Hemolytic anemia

A

Normonlastss, reticulocytosis, cholelith

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Morphology of Hemolytic anemia

A

Normochtic, normochromoic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Genetic of hereditary apherocytosis

A

Ad

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Spheorid cell, less deformable

A

hereditary apherocytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Mutation of ankyrin band 3 /

Spectrin

A

hereditary apherocytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Congestion of cords of billroth inc # of cords of billroth, inc phagocytes in spleen

A

hereditary apherocytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Due to parvovirus b19

A

hereditary apherocytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Due to env mononuc

A

hereditary apherocytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Small dark nuclear remants preaent n rbc os asplenic pts

A

Howell jolly bodies in splenomegaly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Xnlinked recessive disorder, reduce ability rbc to protect themselves agaisnt oxidative ij and lead to hemolysis

A

G6pd

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What infn causeG6pd

A

Biral hepa, pneumonia, typhoid fevery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Drugs cause G6pd

A

Antimalarial, sulfa, nitrofurantoin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Protective against malaria

A

G6pd

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Rate lim of pp

A

G6pd

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Reduce nadp to nadph

A

G6pd

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Membrane bound precipitates in denatured globin chains

A

Heinz bodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Rbcs wt damaged membranes

A

Bkte cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Acute intravasculae hemolysis wrhin 2-3 days- anemia, hbnuria, hbnemia

A

G6pd

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Recovery helarded by reticuloscytosis

A

G6pd

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Autosomal recessive hemoglobinopathy, african

A

Sickle cell anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Small nuclear remannts in rbc dt asplenia

A

Howell jolly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Trapping of sickles cell leads to splenic fibrosis

A

Autosplenectomy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Dehydrated rbcs wt bulls eye appearance

A

Trget cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Rbc like curved blades

A

Sickled cellt

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Episode of hupoxid inj and infarct

A

Vasooclusive crisis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Massive entrapment of sickles crll leads to rapud splenic enlargemnt hypovolemia

A

Sequestration crisi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Infection of rbc progenitors by parvo b19

A

aastoc anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Inability to con urine

A

Hypostjenuria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Inc susceptibility wr encapsulated organis

A

Sickle cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Prom cheeckbones, crewvut skull appearnce

A

Sickle cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Best initial dx for sickle cell

A

Pbs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Dx gold standard

A

hb electropheresis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Doc fir sickle crll ania

A

Hydroxyurea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

Chipmunk facies, crew cut skull, splenomegaly, hemochromotasosi

A

Thalassemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

Codixytes

A

Thalassemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Basophilic stippling

A

Thalassemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

Microcytic hupochrmoic

A

Thalassemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

1 tx for hemochromatosi

A

Phleb

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

Id nonresponsive

A

chelation wt deferoxamine

42
Q

Intravasculat hemolysis dt inc complement mediated rbc lysis

A

Pnh

43
Q

Dx of pnh

A

Flow cytometry

44
Q

Low rbc during sleep

A

Pnh

45
Q

Rm temp death of rbc

A

Warma agglutinin

46
Q

Death rbc by col

A

Cold aglutinin seen wt mycoplasma pn

47
Q

Ig cold hot

A

Igm igg

48
Q

Igg ti bloodw

A

Direct coombs

49
Q

Normal rbc to pts serum

A

Indirect coombs

50
Q

Rbc damaged thru passing narrowed vessels

A

Microangiopathic

51
Q

Microangiopathic seen in

A

Dic, ttp, hus, sle

52
Q

Morpho microangiopathic

A

Sccjistocytes, blur cell

53
Q

Impairment if dna synt leads to distinctive morphologic chanes

A

Megaloblastic anemia

54
Q

Morph of megaloblastic

A

Macoovalocyte if rbc, hypersegmented neutr

55
Q

Diff deficiency if vit b12 folate👻

A

Neurologic sx🎅

56
Q

Parasituc infxn of megaloblastuc

A

Diphy🎣

57
Q

Tx 🎣

A

Prai

58
Q

Caused by autoimmune gastritis and fec if

A

Pernicious anemia

59
Q

Atrophy of fundic glands, intestinaluziation

A

Pernicious anemia

60
Q

Shiny glazed beefy tongue

A

Pernicious anemia

61
Q

Demyelination of dirsala nd lat tracts of sc

A

Pernicious anemia

62
Q

Stage 1 scholling

A

Vit b12

63
Q

Schilling stage 2

A

If

64
Q

Low stage 1 nirmal stage 2

A

Pernicious anemia

65
Q

Parasitic infxn lead to microcytic hypochromic anemia

A

Hookworms

66
Q

Doc for hookworlms

A

Albendazole

67
Q

Morpho ida

A

Disappearance if stainable iron fr macrophages in marrow in prissiona blu

68
Q

S/sx o ia

A

Pica, plummer vinson syndrome ( esophageal webs, atrophic glossitis

69
Q

Stimulate hepcidin

A

6

70
Q

Reduce iron transerfr stirage pool to bone marriw

A

Hepsidin

71
Q

Syndrome of chronic primary hematopoietic failure and atendant pancytopenia

A

Aplastic anemia

72
Q

Ab cause idiosyncratzic aplastic anemia

A

Chloram

73
Q

Chemical causes aplastic anemia

A

Benzene

74
Q

Morph aplastic anemia

A

Hypocellular bm wt fat cells dry tap

75
Q

Diff aa and myelodysplastic anemia

A

Mds has hypercellular

76
Q

Selective hypoplasia of marriw erythroid. Normal granulpoiesis and thrombopoiesus

A

Pure red cella palsia

77
Q

Plt less than 100,00

A

Thrombocytopeniat

78
Q

Spont blleed

A
79
Q

Caused bu antipaletelet antibidy

A

Itp

80
Q

Sec to viral infxn

A

Ito

81
Q

Morfo itp

A

Congestionnof sinusoids enlargement of follicles, megathrombocytes

82
Q

Mist feared complication of itp

A

Intracranial bleed

83
Q

Tx ito

A

Glucocorticoid, splenectomy, rituxab

84
Q

Spectrum of ttp and hus

A

Thrombotic microangiopathis

85
Q

Pentad if ttp

A

Fever, thrombocytopenia, mha, neuro def, renal failure

86
Q

Triad hus

A

Microangiopathic hemolytic anemia, thrombocytopenia, renal failure

87
Q

Def of adamst13

A

Ttp

88
Q

Causes by shiga like toxin ehec

A

Hus

89
Q

Inc bleeding time

A

Platelet dysfxn

90
Q

Defective plt adhesion

A

Bernard soulier

91
Q

Dec gp 2b-3a

A

Glanzman

92
Q

Sx of bleeding + normal platelet

A

Vwd

93
Q

Tx of vwd

A

Desmoprrssin

94
Q

Most common life threatening assoc wt life threatening bleeding

A

Hemophilia a

95
Q

Chrisas disease

A

Heophilia b

96
Q

Acute, subacute or chronic thrombohemorrhaguc disorder

A

Dic

97
Q

Causes of dic

A

Sepsis, trauma, obstetric comp, pancreetitis, malig, mephrotic synd, transfusion

98
Q

Fibrin thrombi lead to massive adrenal hemorrhages

A

Water friderichsen synd

99
Q

Post partum pituitary necrosi

A

Sheehan synd

100
Q

Widespread microtjrombi onnplacenta

A

Toxemia n preg

101
Q

Tests for dic

A

Fibrinogen, plt, pt/ptt, fibrin, degradation products

102
Q

Premature destruction of rbc, elev erythropoeitin level. Accumulation of hb pro

A

Hemolytic anemia