Rate Limiting Enzymes Flashcards
glyolysis
phosphofructokinase 1 (PFK-1)
gluconeogeneis
Fructose 1,6 bisphosphatase
TCA cycle
isocitrate dehydrogenase
Regulators of glycolysis
+: AMP, fructose 2,6 BP
-: ATP, citrate
regulators of gluconeogenesis
+:ATP
-:AMP, fructose 2,6 BP
regulators of TCA
+: ADP
-: ATP, NADH
Glycogen synthesis
glycogen synthase
glycogen synthesis regulators
+: glucose, insulin
-: Epi, glucagon
Glycogenolysis
glycogen phosphorylase
Glycogenolysis regulators
+: AMP, epi, glucagon
-: insulin, ATP
HMP shunt
Glucose 6 phosphate dehydrogenase (G6PD)
HMP shunt regulators
+; NADP+
-: NADPH
De novo pyrimidine synthesis
carbamoyl phosphate synthetase II
De novo purine synthesis
glutamine-PRPP amidotransferase
de novo purine synthesis regulators
– AMP, IMP, GMP