Rate-determining Regulators Flashcards
1
Q
Fructose-1,6-bisphosphatase (Gluconeogenesis)
A
- AMP, F-2,6-BP
2
Q
Isocitrate dehydrogenase (TCA)
A
+ ADP
- ATP, NADH
3
Q
Glycogen Synthase (Glycogenesis)
A
+ G-6-p, insulin, cortisol
- epinephrine, glucagon
4
Q
Glycogen phosphorylase (Glycogenolysis)
A
+ epinephrine, glucagon, AMP
- G-6-P, insulin, ATP
5
Q
G6PD (HMP)
A
+ NADP+
- NADPH
6
Q
Carbamoyl phosphate synthase 2 (de novo pyrimidine)
A
+ ATP, PRPP
- UTP
7
Q
Glutamine-PRPP amidotransferase (de novo purine)
A
- AMP, IMP, GMP
8
Q
Carbamoyl phosphate synthase 1 (urea cycle)
A
+ N-acetylglutamate
9
Q
Acetyl-CoA carboxylase (fatty acid synthesis)
A
+ insulin, citrate
- glucagon, palmitoyl-CoA
10
Q
HMG-CoA synthase (Ketogenesis)
A
No regulators
11
Q
HMG-CoA reductase (cholesterol synthesis)
A
+ insulin, thyroxine
- glucagon, cholesterol
12
Q
Phosphofructokinase 1 (glycolysis)
A
+ AMP, F-2,6-bp
- ATP, citrate
