Classic Labs/Findings II

Question 1

Electrical alternans (alternating amplitude on EKG)

Answer 1

Pericardial tamponade

Question 2

Enlarged cells with intranuclear inclusion bodies

Answer 2

“Owl eye” appearance of CMV

Question 3

Enlarged thyroid cells with ground-glass nuclei with central clearing

Answer 3

“Orphan Annie” eyes nuclei (papillary carcinoma of the thyroid)

Question 4

Eosinophilic cytoplasmic inclusion in liver cell

Answer 4

Mallory body (alcoholic liver disease)

Question 5

Eosinophilic cytoplasmic inclusion in nerve cell

Answer 5

Lewy body (Parkinson disease)

Question 6

Eosinophilic globule in liver

Answer 6

Councilman body (viral hepatitis, yellow fever), represents hepatocyte undergoing apoptosis

Question 7

Extracellular amyloid deposition in gray matter of brain

Answer 7

Senile plaques (Alzheimer disease)

Question 8

Giant B cells with bilobed nuclei with prominent inclusions (“owl’s eye”)

Answer 8

Reed Sternberg Cells (Hodgkin’s lymphoma)

Question 9

Glomerulus like structure surrounding vessel in germ cells

Answer 9

Schiller Duval bodies (yolk sac tumor)

Question 10

Hair on end (Crew-cut) appearance on x-ray

Answer 10

ß-thalassemia, sickle cell disease (marrow expansion)

Question 11

hCG elevated

Answer 11

Choriocarcinoma, hydatiform mole (occurs with and without embry, and multiple pregnancy)

Question 12

Heterophile antibodies

Answer 12

Infectious mononucleosis (EBV)

Question 13

Heart nodules (granulomatous)

Answer 13

Aschoff bodies (rheumatic fever)

Question 14

Hexagonal, double-pointed, needle-like crystals in bronchial secretions

Answer 14

Bronchial asthma (Charcot-Leyden crystals: eosinophilic granules)

Question 15

High-level of D-dimers

Answer 15

DVT, PE, DIC

Question 16

Hilar lymphadenopathy, peripheral granulomatous lesion in middle or lower lung lobes (can calcify)

Answer 16

Ghon complex (1° TB: Mycobacterium bacilli)

Question 17

“Honeycomb lung” on x-ray or CT

Answer 17

Interstitial pulmonary fibrosis

Question 18

Hypercoagulability (leading to migrating DVT’s and vasculitis)

Answer 18

Trousseau syndrome (adenocarcinoma of pancreas or lung)

Question 19

Hypersegmented neutrophils

Answer 19

Megaloblastic anemia (B12 deficiency: neurlogic symptoms; folate deficiency: no neurological symptoms)

Question 20

Hypertension, hypokalemia, metabolic alkalosis

Answer 20

Conn syndrome (primary hyperaldosteronism)

Question 21

Hypochromic, microcytic anemia

Answer 21

Iron deficiency anemia, lead poisoning, thalassemia (fetal hemoglobin sometimes present)

Question 22

Increased AFP in amniotic fluid/maternal serum

Answer 22

Dating error, anencephaly, spina bifida (neural tube defects)

Question 23

Increased uric acid levels

Answer 23

Gout, Lesch-Nyhan syndrome, tumor lysis syndrome, loop and thiazide diuretics

Question 24

Intranuclear eosinophilic droplet-like bodies

Answer 24

Cowdry type A bodies (HSV or VZV)

Question 25

Iron-containing nodules in alveolar septum

Answer 25

Ferruginous bodies (asbestosis: increased chance of mesothelioma)

Question 26

Keratin pearls on skin biopsy

Answer 26

Squamous cell carcinoma

Question 27

Large granules in phagocytes, immunodeficiency

Answer 27

Chediak-Higashi disease (congenital failure of phagolysosome formation)

Question 28

“Lead pipe” appearance of colon on abdominal imaging

Answer 28

Ulcerative colitis (loss of haustra)

Question 29

Linear appearance of IgG deposition on glomerular and alveolar basement membranes

Answer 29

Goodpasture syndrome