rate determining enzymes in metabolic processes

Question 1

Glycolysis?

Answer 1

phosphofructokinase-1 PFK-1

Positive:
AMP, F2,6BP

Negative:
ATP, citrate

Question 2

Gluconeogenesis

Answer 2

Fructose 1,6 bisphosphate

positive: aTP, acetylCoA
negative: AMP, fructose 2,6BP

Question 3

TCA cycle

Answer 3

isocitrate dehydrogenase

Positive: ADP

Negative: ATP, NADH

Question 4

Glycognesis

Answer 4

glycogen synthase

Positive: G6P, insulin, cortisol

Negative: epi, glucagon

Question 5

Gycogenolysis

Answer 5

Glycogen phosphorylase

positive: epi, glucagon, AMP

Negative: G6P, insulin, ATP

Question 6

HMP shunt

Answer 6

glucose-6-phosphate dehydrogenase

positive: NADP+

Negative: NADPH

Question 7

De novo pyrimidine syntheisis

Answer 7

carbamoyl phosphate synthetaste II

Question 8

de nova purine synthesisi

Answer 8

Glutamine phosphoribozylpyrophosphate (PRPP) amidotransferase

negative: AMP, inosine monophosphate (IMP), GMP

Question 9

Urea cycle

Answer 9

carbamoyl phosphate synthetase 1

postive: n-acetylglutamate

Question 10

Fatty acid synthesis

Answer 10

Acetyl CoA carboxylase (ACC)
positive: insulin, citrate

negative: glucagon, palmitoyl CoA

Question 11

Fatty acid oxidation

Answer 11

Carnitine acyltransferase I

negative: malonyl coA

Question 12

Ketogenesis

Answer 12

HMG CoA synthase

Question 13

Cholesterol synthesis

Answer 13

HMG CoA reductase

positive: insulin, thyroxine
negative: glucagon, cholesterol