Rash Flashcards

1
Q

Under which headings would you describe an individual lesion?

A
SCAM
Size, shape
Colour
Associated secondary change
Morphology, margin
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2
Q

If a lesion is pigmented, the presence of which features increase the likelihood of melanoma?

A

Asymmetry (lack of minor image in any of the four quadrants)
Irregular Border
Two or more Colours within the lesion
Diameter > 6mm

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3
Q

Differentiate between macule, patch, plaque, papule, nodule, vesicle, pustule and bulla.

A

Macule- flat lesion less than 1 cm, without elevation or depression
Patch- flat lesion greater than 1 cm, without elevation or depression
Plaque- flat, elevated lesion, usually greater than 1 cm
Papule- elevated, solid lesion less than 1 cm
Nodule- elevated, solid lesion greater than 1 cm
Vesicle- elevated, fluid-filled lesion, usually less than 1 cm
Pustule- elevated, pus-filled lesion, usually less than 1 cm
Bulla- elevated, fluid-filled lesion, usually greater than 1 cm

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4
Q

What are the four main rashes?

A
maculopapular
erythematous
petechial/purpuric
vesiculo/bullous
(look up pics)
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5
Q

Describe a rash consistent with psoriasis.

A

red demarcated plaques, with secondary crusting, erosions and scale on extensor surfaces

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6
Q

Describe a systematic approach to discussing rashes.

A
Colour
Size
Morphology
Pattern
Distribution
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7
Q

What kind of descriptions would you use for the pattern of a rash?

A
discrete or confluent?
demarcated or indistinct?
linear?
target?
annular (ring-shaped)?
discoid?
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8
Q

What kind of descriptions would you use for the distribution of a rash?

A
generalised/localised
central/peripheral
flexural/extensor surfaces
dermatomal area
site-specific
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9
Q

What rash may become secondary to vancomycin therapy?

A

‘red man syndrome’ - widespread, urticarial erythematous rash

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10
Q

What is Adult-onset Still’s disease?

A

rare systemic autoinflammatory disease characterized by the classic triad of fevers, joint pain, and a distinctive salmon-coloured bumpy rash which only appears when pyrexial

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11
Q

What is the word you would use to describe someone who is red all over?

A

erythroderma

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12
Q

Name some conditions which present with erythroderma.

A
psoriasis erythroderma
eczema
pityriasis rubra pilaris
cutaneous adverse drug reaction
cutaneous lymphoma
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13
Q

How does cutaneous lupus typically present?

A

annular patchy rash or discoid plaque type

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14
Q

Name three drugs which may worsen psoriasis.

A

antimalarials, B blockers, lithium

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15
Q

What is the prevalence of psoriatic arthritis among patients with psoriasis?

A

5-30%

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16
Q

Which areas are important to examine in a patient with suspected psoriasis?

A

flexures, nails, scalp, joints, genital regions, post-auricular regions

17
Q

Which nail changes are associated with psoriasis?

A

pitting, onycholysis, subungual hyperkeratosis, leukonychia, oil drop

18
Q

What are the six different types of psoriasis?

A

plaque, guttate, flexural, palmoplantar, pustular, erythrodermic

19
Q

What often triggers guttate psoriasis?

A

streptococcal throat infections

20
Q

How does guttate psoriasis present?

A

usually seen in children and adolescents

numerous small red patches develop on trunk, often clears in a few months but plaque psoriasis may develop later

21
Q

Describe the presentation of flexural psoriasis.

A

submammary axillary and anogenital folds - sharply demarcated, glistening salmon pink in colour, can have superimposed candida

22
Q

Which type of psoriasis can present with significant scaling and painful fissures of palms and soles?

A

palmoplantar

23
Q

How does pustular psoriasis present?

A

localised palmoplantar pustulosis (recalcitrant, multiple sterile pustules on palms and soles) or generalised pustular psoriasis which is an emergency

24
Q

What is the most common arthropathy in psoriatic arthritis?

A

asymmetric mono or oligoarthritis

25
What are the first line managements in a patient with psoriasis?
``` emollients topical steroids vitamin D analogues coal tar weight loss (relation to metabolic syndrome) alcohol cessation ```
26
Where would you examine for evidence of mucosal involvement?
conjunctiva genitals and urinary tract lips and mouth
27
What are some of the skin features of TEN/SJS?
diffuse erythema macules targetoid lesions skin detachment, erosions and flaccid blisters
28
What is Nikolsky sign?
when blisters and erosions appear when the skin is rubbed gently - TEN/SJS
29
What drugs can cause SJS/TEN?
allopurinol, NSAIDs, anti-epileptics e.g. carbamazepine, antibiotics
30
SJS and TEN are considered part of a spectrum of disease, based on the degree of skin involvement. Discuss.
SJS: <10% BSA affected, plus widespread erythematous/purpuric macular rash or flat atypical targets SJS/TEN overlap: 10-30%, widespread purpuric macules or flat atypical targets TEN: epidermal detachment > 30%
31
Discuss the scoring system in place for assessing the severity of SJS/TEN to predict mortality.
``` age > 40 years malignancy HR > 120 initial % epidermal detachment >10% serum urea > 10 mmol/L serum glucose > 14 mmol/L serum bicarb < 20 mmol/L ```
32
What should be considered a part of the management of SJS/TEN?
``` identify and stop culprit drug fluid balance temperature control barrier nursing glycaemic control skin care mouth and eye care analgesia identification and treatment of infection VTE prophylaxis ```
33
What is the bacteria which is involved in the pathogenesis of acne?
Propionibacterium acnes - if a follicle becomes blocked by excess sebum or skin cells, the bacteria can multiply causing inflammation within the follicle
34
Name some drugs which can induce or worsen acne.
topical and oral corticosteroids, lithium, ciclosporin, progesterone only contraceptives
35
What kind of topical and systemic treatments are available for acne?
topical: Benzoyl peroxide, Adapalene (topical retinoid), Clindamycin systemic: COCP, doxycycline, isotretinoin (oral retinoid)
36
Why should patients who are taking isotretinoin avoid alcohol?
due to the risk of transaminitis
37
What are the five patterns of psoriatic arthropathy?
``` Distal interphalangeal arthritis Symmetrical polyarthritis Asymmetrical oligoarthritis Spondyloarthropathy Arthritis mutilans ```
38
What are the classic features of basal cell carcinoma?
rolled edge, pearly appearance and telangiectasia
39
What are the different classes of steroid and give an example of each?
mild - Hydrocortisone moderate - eumovate potent - betnovate very potent - dermovate