Rapid Review Flashcards
Lipid soluble hormones
thyroid hormone, steroid hormones (estrogen, aldosterone, cortisol, testosterone, etc,) fat soluble vitamin receptors.
Proopiomelanocortin (POMC) is a precursor to what
produces beta-endorphin(endogenous opioids); ACTH and MSH (bronze)
Somatotropin hormones
GH, prolactin
Ecthyma gangrenosum
pseudomonas; perivascular bacterial invasion of arteries and veins in the dermis with subsequent release of EXOTOXIN causing necrosis and ulcerations (Dalmatian in sketchy)
Alpha and Beta interferons (secretion, production, moa?)
Are secreted in response to virally infected cells. These interferons generate enzymes capable of halting protein synthesis in virally infected cells. Enzymes become active upon detection of dsRNA, which is only present in virally infected cells.
Treatment of hepatic encephalopathy
lactulose: bacteria convert lactulose into acetic acid and lactic acid promoting ammonia excretion; Ramifixan is an antibiotic that disrupts GI flora and prevents the formation of ammonia.
Duodenal ulcer
Pain better with food, can be caused by H Pylori, very low risk to become malignant; Zollinger Ellison association
refractory peptic ulcers with high gastrin secretion (gastrinoma of the duodenum or pancreas), associated with MEN 1, causes GERD, and diarrhea
Zollinger Ellison
pheochromocytoma vs neuroblastoma
neuroblastoma is what its called in children; pheo- is in adults
Annular Pancreas
abnormal rotation of ventral pancreas–> forms ring encircling part of the duodenum –> narrowing–> obstruction
Pancreatic Divisum
ventral and dorsal parts fail to fuse at 8 weeks. benign but can cause pancreatitis or abdominal pain
Obstructive jaundice with palpable, non-tender gallbladder
Courvoisier sign; associated with pancreatic adenocarcinoma
Migratory thrombophlebitis- redness, tenderness on palpation fo extremities (migrating DVTs and vasculitis)
Trousseau syndrome- associated with pancreatic adenocarcinoma OR adenocarcinoma of the lung
Reynolds pentad
Jaundice, RUQ pain, fever– all charcot’s triad + altered mental status and shock (hypotension) associated with Ascending cholangitis
Charcot triad
jaundice, fever, RUQ pain- Ascending cholangitis
S Bovis
Colon Cancer
Crescendo-decrescendo systolic ejection murmur and soft S2 (ejection click may be present)
Aortic Stenosis- Systolic Murmur; Pulsus parvus et tarsus- pulses are weak and delayed; radiates to carotids
Holosystolic, high pitching “blowing” murmur
Mitral (loudest at apex; radiates toward axilla) or tricuspid (loudest at tricuspid area; RV dilation); rheumatic fever infective endocarditis- systolic murmur
Late systolic crescendo murmur w/ mid systolic click
Mitral Valve prolapse; Marfans, AD-PCKD, fragile-X Syndrome; Ehlers-Danlos- systolic murmur; Chordae rupture, rheumatic fever
Holosystolic harsh sounding murmur
ventricular septal defect- systolic murmur
High pitched Blowing in early diastolic decrescendo murmur
Aortic regurgitation; wide pulse pressure, bobbing head, headaches
Etiology: aortic root dilation, bicuspid aortic valve, endocarditis, rheumatic fever
Follows opening snap; delayed rumbling mid-to-late diastolic murmur.
Mitral Stenosis; often late sequels of rheumatic fever
Complication: leads to LA dilation–> compression of recurrent laryngeal nerve–> dysphagia/ hoarseness via compression of esophagus/ left RcLn. Diastolic
Continous machine like murmur
PDA; continuous murmur; Loudest at S2
Congenital Rubella or prematurity
Acute erosive gastropathy
erosion extends into the muscularis mucosa but not beyond it