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1
Q

Increase risk of Digoxin toxicity

A

Quinidine, cimetidine, amiodarone, CCBs

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2
Q

Competition for albumin binding sites

A

Warfarin, ASA, phenytoin

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3
Q

Hemolysis in G6PD

A

Sulfonamides, INH, ASA, ibuprofen, Nitrofurantoin, primaquine, pyrimethamine, chloramphenicol

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4
Q

Gynecomastia

A 
Some Excellent Drugs Create Awesome Knocker
Spironolactone
Estrogens
Digitalis
Cimetidine
Alchohol (chronic)
Ketoconazole
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5
Q

Steven-Johnson Syndrome

A

Anticonvulsants
Sulfonamides
penicillins

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6
Q

Photosensitivity

A

Tetracycline, amiodarone, sulfonamides

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7
Q

Drug-induced SLE

A

Procainamide, hydralazine, INH, penicillamine, chlopromazine, methyldopa, quinidine

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8
Q

Rx for anticholinesterases/organophosphate OD

A

Atropine, pralidoxime

presents with SLUDGE

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9
Q

Rx anticholinergic OD

A

Physostigmine

Red as a beat, dry as a bone, mad as a hatter

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10
Q

Betablocker OD Rx

A

glucagon

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11
Q

barbiturate OD Rx

A

urine alkalinization, dialysis, supportive

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12
Q

Benzos OD Rx

A

flumazenil

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13
Q

Black widow bite Rx

A

Ca gluconate, methocarbamol

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14
Q

Cyanide OD Rx

A

hydroxycobalamin, amyl nitrate, sodium nitrate, sodium thiosulfate

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15
Q

Arsenic Rx

A

succimer, dimercaprol (penicillamine)

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16
Q

Copper Rx

A

Penicillamine

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17
Q

Digitalis OD

A

normalize K, anti-dig Fab, avoid giving Ca, Mg, or lidocaine

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18
Q

Salicylate OD Rx

A

Urine alk, dialysis, charcoal

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19
Q

tPA, streptokinase Rx

A

aminocaproic acid

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20
Q

Amantadine SE

A

Ataxia, Livedo reticularis

dopamine agonist

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21
Q

Aminoglycosides SE

A

ototox, nephrotox (acute tubular necrosis)

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22
Q

Amiodarone SE

A

Acute: AV block, hypotension, brady
Chronic: pulm fibro, bluish discoloration, arrhythmia, hypo/hyperthyroid, corneal deposits

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23
Q

Azoles SE

fluconazole

A

Inhibition of P-450 enzymes

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24
Q

AZT SE

A

thrombocytopenia, megaloblastic anemia

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25
Q

carbamazepine SE

A

induce p450
AGRANULOCYTOSIS
liver tox

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26
Q

Chloramphenicol SE

A

Gray baby syndrome, aplastic anemia

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27
Q

Cisplatin SE

A

nephrotox, acoustic nerve damage

28
Q

Clonidine SE

A

severe rebound HA and HTN

29
Q

Clozapine SE

A

agranulocytosis

30
Q

cyclophosphamide SE

A

hemorrhagic systitis (give MESNA)

risk for bladder cancer

31
Q

Digoxin SE

A

GI disturbance (nausea)
Yellow vision changes
Arrythmias (junctional or SVT)
atrial tach with AV block

32
Q

Doxorubicin SE

A

Cardiotoxicity

33
Q

Fluoroquinolones SE

A

carilage damage in children, Achilles tendo rupture in adults

34
Q

Furosemide SE

A

Ototox, hypoK, nephritis, gout

35
Q

Gemfibrozil SE

36
Q

Halothane SE

A

malignant hyperthermia

hepatotox

37
Q

HCTZ SE

A

Hypo-K,Na,Mg

Hyper-glyc,uremia,calcemia

38
Q

Hydralazine SE

A

drug induced SLE

39
Q

INH SE

A

Peripheral neuropathy (give pyridozine/B6)
Hepatotox, inhib p450, SZ
hemolysis in G6PD

40
Q

MAOIs (selegeline)

A

Hypertensive Tyramine Reaction, Serotonin Syndrome with meperidine

41
Q

methotrexate SE

A

Hepatic fibrosis, pneumonitis, anemia (folate inhibition)

42
Q

methyldopa SE

A

Drug induced SLE

43
Q

Metronidazole SE

A

disulfiram rxn, vestibular dys, metallic taste

44
Q

Penicillamine SE

A

Drug induced SLE

45
Q

Phenytoin SE

A

Gingival hyperplasia, hirsutism, nystagmus, diplopia, ataxia, arrhythmia, teratogen

46
Q

Procainamide SE

A

Drug-Induced SLE

47
Q

PTU SE

A

agranulocytosis, aplastic anemia

48
Q

Quinidine SE

A

torsades, cinchonism (HA, tinnitus), Drug-induced Lupus

49
Q

Succinylcholine SE

A

malignant hyperthermia, hyper K

50
Q

Tetracyclines SE

A

tooth discolor, photosens, fanconi syndrome, GI distress

dont give to kids under 8

51
Q

Valproate SE

A

teratogen = neural tube defect, rare fatal hepatotox

52
Q

Vinblastine SE

A

severe myelosuppression

53
Q

Vincristine SE

A

peripheral neuropathy, paralytic ileus

54
Q

Vit A Def

A

night blindness, dry skin

55
Q

Vit B1 (thiamine) Def

A

Beriberi (polyneuritis, dilated cardiomyopathy, hyigh-output CHF, edema)
Wernicke-Korsakoff (gait, eye problems, confabulation)

56
Q

Vit B2 (riboflavin) Def

A

Angular stomatitis, cheilosis, corneal vascularization

57
Q

Vit B3 (niacin) Def

A

Pellagra DDD (diarrhea, dermatitis, dementia)

58
Q

Vit B5 (pantothenate) Def

A

Dermatitis, enteritis, alopecia, adrenal insufficiency (hypotension, hyponatremia, hyperk)

59
Q

Vit B6 (pyridoxine) Def

A

Convulsions, hyperirritability

60
Q

Vit C Def

A

Scurvy (swollen gums, bruising, anemia, poor wound healing, curly hair?)

61
Q

Vit E Def

A

Fragile RBCs –> hemolysis?

62
Q

Vit K Def

A

neonatal hemorrhage, high PT and aPTT

63
Q

Biotin Def

A

Dermatitis, enteritis, caused by raw egg ingestion

64
Q

Mg deficiency

A

weakness, muscle cramps, tremors, choreoathetoid mvmt, hypocalcemic tetany

65
Q

Selenium def

A

cardioyopathy (Keshan dz)

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