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Random Associations Flashcards

1
Q

Most common inherited hypercoagulability

A

Factor V Leiden

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2
Q

Most common inherited bleeding disorder

A

von Willebrand Dz

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3
Q

Most common inherited hymolytic anemia

A

HS, test is osmotic fragility

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4
Q

Anemia with absent radii and tumbs, diffuse hyperpigmentation, cafe au lait spots, microcephaly, pancytopenia

A

Fancony anemia

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5
Q

meds that cause aplastic anemia

A

Chloramphenicol, sulfonamides

chemotherapy and radiation

HIV, hepatitis, parvo B19, EBV

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6
Q

TTP pentad?

A

FAT RN
Fever, anemia, thrombocytopenia, Renal dys, neuro abn

Rx: plasmapheresis, roids
plt txfusion contraindictated!

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7
Q

HUS triad?

A

Anemia, thrombocytopenia, AKI

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8
Q

14 yo girl, prolonged bleeding after dental surgery and menses, normal PT, normal or high PTT

A

vWillebrand Dz
Rx: desmopressin, FFP, cryo-ppt

high PTT because vWF stabilizes factor VIII

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9
Q

10 yo boy, fever, weight loss, night sweats, antierior mediastinal mass

A

Suspect Non-Hodgkin Lymphoma

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10
Q

Reed-Sternberg cells

A

Hodgkin lymphoma

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11
Q

80 yo with fatigue, lymphadenopathy, splenomegaly, lymphocytosis (isolated)

A

CLL

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12
Q

Fever, bone pain, splenomegaly, pancytopenia in CML pt

A

Blast crisis, life threatening

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13
Q

Auer Rods

A

AML

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14
Q

AML subtype associated with DIC?

A

M3, Rx with Retinoic Acid

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15
Q

50 yo with early satiety, splenomegaly, bleeding. t(9,22).

A

CML

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16
Q

boy with chronic sinopulmonary infections and negative nitroblue tetrazolium test

A

Chronic granulomatous disease

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17
Q

Child with eczema, thrombocytopenia, high IgA

A

Wiskott-Aldrich syndrome

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18
Q

4 month old boy with life-threatening pseudomonas infection

A

Bruton’s X linked agammaglobluinemia (no b cells)

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19
Q

Vaccinations at 6 mo well child

A

HBV, DTaP, Hib, IPV, PCV, rota

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20
Q

Lung cancer associated with hypercalcemia

A

Squamous cell carcinoma (NSCLC)

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21
Q

lung cancer associated with SIADH

A

Small Cell Lung Cancer (SCLC)

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22
Q

Lung cancer associatd with Lambert Eaton

A

SCLC

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23
Q

RTA associated with abn H+ secretion and nephrolitiasis

A

Type I distal

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24
Q

RTA with abn HCO3- reabsorption and rickets

A

Type II proximal

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25
Q

RTA associated with low aldosterone (low Na, High K)

A

Type IV distal

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26
Q

Most common type of nephrolith

A

calcium oxalate

27
Q

Test of choice for nephrolith

A

NONCON ct scan

US next best?

28
Q

Hematuria, HTN, oliguria

A

Nephritic Syndrome

29
Q

Proteinuria, hypoalbuminemia, hyperlipidemia, edema

A

nephrotic syndrome

30
Q

Most common nephrotic syndrome in adults

A

Focal segmental glomerulosclerosis

31
Q

Nephritic syndrome 3 days after URI, normal C3

A

IgA nephropathy (Berger), immune complex

roids for some, ACEI if proteinuria

32
Q

Glomerulonephritis with deafness

A

Alport Syndrome

33
Q

Glomerulonephritis with hemoptysis

A

Goodpastures or granulomatosis with polyangitis

34
Q

Red cell casts

A

glomerulonephritis/nephritic syndrome

35
Q

Eosinophils in urine

A

allergic interstitial nephritis

36
Q

Waxy casts and maltese crosses

A

nephrotic syndome

37
Q

muddy brown casts

A

acute tubular necrosis

38
Q

drowsiness, asterixis, nausea, pericardial friction rub

A

Uremic syndrome in renal failure

39
Q

hematuria in 50 yo smoker

A

bladder cancer

40
Q

hematuria, flank pain, palpable flank mass

A

Renal Cell Carcinoma

41
Q

Testicular cancer with high beta-HCG

A

choriocarcinoma

42
Q

most common testicular tumor

A

seminoma, a germ cell tumor

43
Q

most common bladder cancer histology

A

transitional cell carcinoma

44
Q

Hematuria, oliguria, 2-6 weeks after infection, low C3

A

Postinfectious glomerulonephritis

45
Q

granulomatosis with polyangiitis systems?

A

kidney + lung + sinus

46
Q

Microscopic polyangiitis systems?

A

kidney + lung

47
Q

Churg-strauss systems?

A

kidney + asthma

48
Q

DDx for low C3 nephritic/nephrotics?

A

post-infectious GN
membranoproliferative GN
mixed cryoglobulinemia
SLE

49
Q

palpable purpura, arthralgias, nephritic/nephrotic, low C3, positive HCV

A

mixed cryoglobulinemia (a type of MPGN?)

50
Q

Strep infection 2-6 weeks ago, oliguria, tea or cola colured urine, Low C3, increased anti-DNase titiers, lumpy-bumpy

A

Postinfectious GN

Supportive care with diuretics for fluid overload

immune complex

51
Q

palpable purpura, arthralgias, abd pain, normal C3

also Rx?

A

Henoch-Schonlein purpura, small vessel vasculitis

supportive +/- roids

52
Q

Respiratory and sinus symptoms, granulomas, cavitary pulmonary lesions causing hemoptysis, renal involvement, positive cANCA

also Rx?

A

Wegeners (gran with polyang)

high-dose roids, cytotoxics, rituximab

53
Q

respiratory symptoms, hemoptysis, renal involvement, pANCA positive, no granulomas

also Rx?

A

Microscopic polyangiitis

roids, cyclophosphamide, ritux

54
Q

Asthma, sinusitis, skin nodules/purpura, peripheral neuropathy, pANCA positive, elevated IgE

also Rx?

A

Eosinophilic gran with polyang (churg-strauss)

roids

55
Q

Rx Goodpasture’s

A

plasma exchange therapy

pulsed roids

56
Q

Sudden onset edema, Hodgkin Lymphoma, NSAID use, tendency for thrombotic events

A

Minimal Change,

effaced podocytes

roids

57
Q

African American, HTN, IV drugs and HIV with nephrotic sympotoms

also Rx?

A

FSGS

pred, cytotoxics, ACEI/ARB for proteinuria

58
Q

Adenocarcinoma or other solid tumor, nephrotic syndrome, Spike and dome deposits of IgG and C3 in basement membrane

also Rx?

A

Membranous nephropathy

pred and cytotoxics

59
Q

Long standing DM, retinopathy, nephrotic syndrome, thick GBM, Increased mesangial matrix, kimmelstiel-Wilson lesion

also Rx?

A

Diabetic nephropathy

glycemic control

60
Q

histology of lupus nephritis

A

mesangial proliferation, subendothelial and or subepithelial immune complex deposits

61
Q

Multiple myeloma or RA (chronic inflammatory disease) with apple-green birefringence on congo red stain, renal involvement, nodular glomerulosclerosis

also Rx?

A

Renal amyloidosis

pred and melphalan

62
Q

HBV, HCV, Tram Track, double layer basement membrane, subendothelial deposits, mesangial deposits, low C3

also Rx?

A

Type 1 Membranoproliferative

roids

63
Q

Four types of stones

A

Calcium oxalate/phosphate - idiopathic hypercalciuria
Struvite - staghorn, proteus, urease producers
Uric Acid - RADIOLUCENT, gout, purine turnover
Cystine - hexagonal crystals, + cyanide nitro test

Step Two (3 decks)

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