Random TTR - Neuro Flashcards
Whata re the most common causes of Meningitis in Children/Teens
Strep Pneumo and Neiserria (colonizes oropharynx and to blood to meninges)
Most common cause meningitis in adults and elderly?
Strep pneumo
Most common cause of meningitis in non-vaccinated infants?
Hflu
Most common viral cause of meningitis?
Coxsackie!
fecal oral
Where do you perform an LP
Between L4-L5
subarachnoid space fluid at iliac crest
without hitting cord
go through skin, ligament, dura, arachnoid but do NOT pierce Pia
What would CSF measurements be for meningitis w/ bacteria? Virus? Fungi?
BActeria - PMNs w/ low glucose, positive gram stain and culture
Virus - Lymphocytes, normal glucose
Fungal - lymphocytes and Low CSF glucose
What chromosomes are NF1 and NF2
NF1 - tumor suppressor NEurofibromin on Chom 17
NF2 - Tumor suppressor MErlin on Chrom 22
What is mutation for FAPCC?
APC gene on chromosome 5
What chromosome is P53 on?
Chromosome 17 (same as NF1)
What chromosome is RB1 on?
Tumor supressor gene on chromsome 13
Retinoblastoma and osteosarcoma
What chromosome is VHL?
Chromsome 3
renal cysts, RCC, Hemangioblatoma
What are the medications that can have the FX of Seizures?
Clozapine Bupropione Isoniazid Ciprofloxacine Imipenem
What gene is messed up in Freidrich’s Ataxia? How does it present? Why does it happen?
AR; Mutation in Chromsome 9 for Frataxin gene which is essential for mitochondrial function
More repeats of GAA leads to mutated gene and diminished levels of Frataxin
Degeneration of Neural tracts and Peripheral nerves
GAIT ATaxia - Spinocerebellar tract
DRG and Dorsal columns lose of propprioception
Kyphoscoliosis and Foot abnormalties (Pes cavus)
HOCM and CHF
DM
What are the most common causes of Meningitis in neonateS?
GBS
Ecoli
Listeria
