Random Questions for Test 1

Question 1

The parameter ‘clearance’ most accurately refers to

Answer 1

A proportionality constant between the rate of drug elimination and the plasma concentration

Question 2

Which of the following statements best describes characteristics of a zero-order
pharmacokinetic process?

Answer 2

The rate of the process is constant at all times

In a zero-order kinetic process, the rate does not depend on the amount or concentration of drug in the compartment.

Question 3

Which type of kinetic rate process is the most common in drug infusion?

Answer 3

zero order; constant rate

Question 4

For a drug that exhibits linear pharmacokinetics, the half-life can be directly used to
determine which of the following? Select the two best answers that apply. Partial credit is
given for each answer.

Answer 4

II. The time to reach a steady-state concentration during an IV infusion
IV. The time to eliminate the drug from the body after an IV bolus

Question 5

SaprorotecTM, a new hair loss treatment, follows one-compartment, first-order elimination,
and has a 12 hr half-life. Once initiated on a daily pill, the treatment is 100% effective at
reversing male-pattern baldness. Unfortunately, after three half-lives, the plasma drug
concentration falls too low, which causes immediate shedding of new hair. Under which
condition might a patient suddenly lose hair?

Answer 5

clearance doubles

Volume of distribution does not affect the steady-state plasma concentration (Css), while
clearance is is inversely proportional to the steady-state plasma concentration. Css = k0/CL.
Therefore, II is correct.