Random Questions Flashcards
What drug can cause blue vision and which drug can cause yellow vision in overdose
Blue vision can be cause by slidenafil and yellow vision is a sign of digoxin toxicity alongside nausea and vomiting
What increases the risk of VTE
Obesity Smoking oral contraceptives Tamoxifen(anti osterogen uses for up to five years in breast cancer it is a prodrug and interacts with paroxteine SSRI are inhibitors) 35+ First degree relative under 45with history of DVT Immobilisation Surgery
What drugs are contraindicated in myasthenia gravis
Quinine (also contraindicated in optic neuritis and tinnitus and can cause QT prolongation )
Benzodiazepines
Amingoglyclasides
Antimuscaranics
What drugs can you not put in a MDS
Topiramate Sodium valproate Nicorandil (mouth ulcers) Dabigatran (avoid if egfr <30) Orodispersible tablers or buccal tablers or sublingual tablers Cytotoxic drugs
Which SGLT is not licensed to be used with pioglitazone for triple therapy
Dapagflozin
Which gliptin DPP4 inhibitor is best in renal impairment and which can cause hepatotoxicity and which does not yet have a place in diabetes management
Linagliptin can be used in renal impairment
Vildagliptin can cause hepatotoxciith
Alogliptin has no place in diabetes management as of yet (25mg OD or 12.5mg or 6.25 mg in renal impairment
Which drugs can cause benign intracranial hypertension (headaches and visual disturbances) for which you must stop taking the drug
Tetracyclines
Lithium
Ciclsporin (moniter potassium and magnesium with this and stop it if antihypertensive drugs do not control a patients hypertension)
What is pyrzanamide contraindicated in ?
Acute attacks of gout
Side notes;
Ticagrelor aspirin and thiazides can cause gout
Remember allopurinol or febuxstat are used for prophylaxis only and should not be used in an acute attack of gout as they can precipitate a attack of gout
Prophylactic drugs should be started 1-2 weeks after a gout attack has settled
Dueduonal ulcer versus gastric ulcer
Deudanal ulcer is worse after eating and pain is worse at night
Gastric ulcer pain is worse on empty stomach and is relieved by food
Drugs lowering seizure threshold
Tramadol
Quinones -e.g. ciprofloaxcin
Isoniazid
Theophylline
Which MR of nifedipine should not be used in GI diseases like IBD as dose form is not appropriate
Adalat LA Valni XL
Side note nifedipine can be used for 8 weeks to treat chronic anal fissures
0.2/0.3%
It can also treat premature labour
Which DOAC can be crushed and added to a NG tube if needed
Rivaroxaban
What are signs of adrenal insufficiency and what drugs can cause them
Fatigue Anorexia Nausea Vomiting Hypotension Hyponatremia Hyperkalemia Hypoglycaemia
Ketoconzole MHRA warning only use oral Keto on ole for Cushing syndrome
And measure cortisol , LFTs (Ketoconzaloe if hepatotoxic moniker before starting and weekly for one month )
Do ECG before hand as ketoconazole can prolong QT interval
Prolonged use of steroids can cause adrenal atrophy leading to adrenal insufficiency
Compliance
Adherence
Concordance
Compliance is the extent to which a patients behaviour match’s the HCPS recommendations
Adherence is the extent to which a patients behaviour match’s the AGREED HCPs recommendations
Adherence can be intentional or unintentional
Concordance is the process by which a patient and HCP come to a mutual agreement regarding treatment
Contraindications of antimuscarinics
GI obstruction
Paralytic ileus (opioids and antispasmodics also contraindicated in paralytic ileus)
Myasthenia gravis
Enlarged prostate
Ullcerative colitis
Toxic megacolon (use of loperamide can cause toxic megacolon in UC therefore avoid )
