Random Q's Flashcards
What is PICO?
Population, Intervention, Comparator, Outcome
Which vitamins cannot be absorbed as they are? How are they absorbed?
Vitamins A, D, E, K, also have to be absorbed via micelles.
Vitamin B12 has to be cleaved to intrinsic factor.
Where is pepsin produced?
Chief cells, produced as pepsinogen
What is FVC?
Forced Vital Capacity (Forced Expiratory Volume)
What are the four principles?
Autonomy, Non Maleficence, Beneficience, Justice
What causes the release of ADH/Vasopresin? What is it’s action?
Angiotensin II, Increase in CO2, Decrease in O2, low blood pressure
(Dehydration)
Causes water retention & vasoconstriction (concentration of urine) via increased aquaporin channels being inserted into DCT
In an ECG, what does the T Wave represent?
Ventricular Repolarisation
Which part of the respiratory tract has the highest resistance?
Trachea
What is required for an autonomous decision?
Mental Capacity
Informed Consent
What does ACE do and where is it produced?
In Lungs, and converts Angiotensin I to Angiotensin II.
What does G represent? What is this?
Vital Capacity. The maximum amount of air a person can expel from the lungs after a maximum inhalation. It is equal to the sum of inspiratory reserve volume, tidal volume, and expiratory reserve volume.
How is the gut divided? What is the blood & nervous supply to each division.
Foregut - oesophagus to first 2/3 of duodenum). Coeliac Trunk. Greater Splanchnic.
Midgut - lower duodenum to first 2/3 of transverse colon. Superior Mesenteric Artery. Lesser Splanchnic.
Hindgut - last third of transverse colon to upper part of anal canal. Inferior Mesenteric Artery. Least Splanchnic.
What is Helicobacter Pylori?
Gram negative bacterium found usually in stomach.
What is Poisseuilles Law?
In laminar flow: a small change in radius significantly affects either flow rate or pressure drop required to achieve the same flow. Bronchoconstriction in asthma is an example of this.
F = Pπr⁴ ÷ 8ƞL
F = flow, P = Pressure drop, R = radius, ƞ = velocity, L = length of pipe.
What is ventilation?
The exchange of air between atmosphere and alveoli. Air moves by bulk flow from a region of high pressure to low pressure.
What is blinding / double blinding?
A blind — or blinded — experiment is an experiment in which information about the test is masked (kept) from the participant, to reduce or eliminate bias, until after a trial outcome is known.
It is understood that bias may be intentional or unconscious, thus no dishonesty is implied by blinding.
If both tester and subject are blinded, the trial is called a double-blind experiment.
3 Situations where you can break confidentiality.
- Court Order 2. When it is in the public interest 3. When you have gained consent from the patient.
What is an airway obstruction (what will the FEV/1 ÷ FVC be?). Give an example
If it i higher than 0.7. Airway obstruction includes narrowing of bronchi and bronchioles, often due to excessive contraction of smooth muscle. Examples COPD and Asthma.
What is the downside of utilitarianism?
Doesn’t Look at the individual
At which week of development does Surfactant develop?
24 weeks
What is ideal blood pressure?
120/80mmHg
What is Boyle’s Law?
The absolute pressure of a gas is inversely proportional to the volume it occupies.
What is the Positive Predictive Value?
The proportion of positive test results that are True Positive.
What is cost effectiveness analysis?
A type of economic evalutation which compares the relative costs and outcomes of different courses of action. In health services, appropriate to monetise health effect. Typically a ratio. QALY (Quality-Adjusted Life Years - commonly used)
What does Angiotensin II do?
Increases Sympathetic Activity,
Tubular Na+ Cl- reabsorption and K+ excretion.
H20 Retention, Aldosterone Secretion.
Arteriolar Vasoconstriction, increase in blood pressure.
Acts on pituitary to secrete ADH.
What hormone causes ovulation?
Lutenizing Hormone
What is Meissner’s Plexus? Is it sympathetic or parasympathetic?
The submucosa plexus, lies in the submucsa of intestinal wall. Parasympathetic nerves coming from superior mesenteric artery.
What is the normal BMI Range?
18.5 - 24.9
How does pain travel to the brain? Where does it go to?
A Fibres - Myelinated - Faster travel - sharp pain
C Fibres - Dull Pain - burning pain
Hormones: Beta endorphins, cortisol
Pain awareness recognised in somatosensory cortex.
What does PTH do?
Regulation of serum calcium
Regulation of serum phosphate
Vitamin D synthesis
Give two examples of screening tests
Bowel Cancer Screening & Breast Cancer Screening
Which organs are Retroperitoneal?
S: suprarenal (adrenal) gland
A: aorta/IVC
D: duodenum (second and third part)
P: pancreas (except tail)
U: ureters
C: colon (ascending and descending)
K: kidneys
E: (o)esophagus
R: rectum
Name a local and hormonal vasodilator?
Local: Bradykinin, Hypoxia, Nitric Oxide
Hormonal: Adrenaline, Atrial Naturetic Peptide
What is Utilitarianism
Maximising Good - most happiness for the largest number of people.
In an ECG, what does the P wave represent?
Atrial Depolarisation
What layers is the epidermis divided into?
Stratum Corneum
Stratum Lucidum
Stratum Granulosum
Stratum Spinosum
Stratum Basale
Name three duties of a doctor (according to Tomorrows Doctors).
Make the care of your patient your first concern Treat patients as individuals and respect their dignity Be honest and open and act with integrity Take prompt action if you think that patient safety, dignity or comfort is being compromised. Never abuse your patients trust in you, or the public’s trust in the profession
What are the functions of the skin?
Protection
Sensation
Temperature Regulation
Immunity
Permits Movement and Growth
Excretion - Regulated by Sweat
Endocrine (Vitamin D Synthesis)
What are the functions of the nasal membrane?
- Cell Recognition
- Semi-Permeable
- Protective Barrier (Impermeable to ions)
- Containment and separation
- Cell signalling
What is Cardiac Output?
Cardiac Output (litres per minute) = Stroke Volume (ml) x Heart Rate (beats per minute)
What is LaPlace’s law?
The pressure within a bubble is equal to twice the surface tension divided by the radius.
P = 2T ÷ r (P = pressure within a bubble, T = surface tension, r = radius).
The smaller the bubble (i.e. the more curved the surface), the larger the radial component. The larger the radial component, the greater the tendancy to collapse. Smaller bubbles have greater internal pressure to keep them inflated
What are the stages of the ‘Stages of Change’ model?
Pre-contemplation, contemplation, preparation, action, maintenance, relapse.
What factors affect heart rate?
Autonomic Innervation, Hormones, Fitness Levels, Age
What is the anion gap?
Difference between the measured cations (positively charged) and measured anions (negatively charged) in serum, plasma and urine. Often calculated when attempting to identify cause of metabolic acidosis. If the gap is greater than normal then high-anion-gap metabolic acidosis is diagnosed.
What are the two types of skin corpuscles, how are they differentiated?
Pacinian and Meissners.
Pacinian are large, deep in the dermis and subcutaneous layer, sense course touch, vibration and tension. Onion appearance
Meissners are small, dermal papillae, sense lighht touch and have a spiral appearance.
What forms the carpal tunnel?
Flexor Retinaculum layer that median nerve and carpal bones are encapsulated within. Compression causes carpal tunnel syndrome.
How are conductive and sensorineural hearing losses differentiated?
Conductive. Problem or blockage in outer or middle ear, prevents sound from being conducted properly. Usually mild or moderate, can be temporary or permanent.
Sensorineural. Results from missing or damaged sensory cells (hair cells) in the cochlea. Can be mild, moderate, severe or profound. Irreversible and usually permanent. Hearing aids, middle ear implants or cochlear implants are reccomended.
What is secreted from Parietal Cells?
HCl & Intrinsic Factor
Which three places do the ureters narrow?
Exit from kidney
Pelvic Brim
Vesico-Ureteric Junction
Which cells begin stomach peristalsis?
Interstitial Cells of Cajal
What are C, D, and F
C : Expiratory reserve volume: the maximal volume of air that can be exhaled from the end-expiratory position
D : Residual Volume: the volume of air remaining in the lungs after a maximal exhalation
F : Functional Residual Capacity : the volume in the lungs at the end-expiratory position
Name a few criteria for screening programmes (Wilson & Jugner)
- The condition should be an important health problem 2. There should be a test that is easy to perform and interpret, acceptable, accurate, reliable, sensitive and specific. 3. There should be an accepted treatment recognised for the disease. 4. The diagnosis and treatment should be cost-effective 5. There should be a recognisable latent or early symptomatic stage
What is an airway restriction (what will the FEV/1 ÷ FVC be?). Give an example
airway restriction if lower than 0.7. Lung Expansion is restricted. (TB, Pulmonary Fibrosis, Infant Respiratory Distress Syndrome - this is due to a deficiency of surfactant in lungs of a premature baby)
What are some of the causes of obesity?
Lack of physical activity, over-eating, sedentary lifestyles, not enough fruit or veg in diet, “Americanisation” of society, office-jobs, stress.
What are the two types of stress?
Distress - Negative
Eustress - Positive
How can you help someone to quit smoking?
NHS Helpline, Nicotine Replacement Therapy, Medication such as Bupropion
What happens when something is chronotropic?
Increase in the rate of contraction.
Krebs Cycle. What are the 8 acids?
Citrate
Isocitrate
Alpha-ketoglutarate
Succinyl Co-A
Succinate
Fumarate
Malate
Oxaloacetate
What is an amphipathic substance?
Both hydrophobic and hydrophilic.
Where is Angiotensinogen produced?
Liver