Random MCQs - high yield

Question 1

Vasodilation mediators?

Answer 1

Prsotaglandins and NO and histamine

Question 2

Vascular permeability mediators?

Answer 2

NO, histamine

Question 3

Pain mediators?

Question 4

Heat mediators?

Question 5

Transmigration of neutrophils is facilitated by what protein?

Answer 5

PECAM-1 (aka CD31)

Question 6

What do neutrophils use to attach to endothelial walls?

Answer 6

Integrins (neut) to integrin ligand (ICAM-1) on endothelial cells

Question 7

What is the alternative (M2) activation pathway of macrophages?

Answer 7

They can be activated to induce wound repeat and healing. This is promoted by IL-4. The classic destructive classical pathway is inhibited by IL-13.

Question 8

Which signalling pathway are most commonly implicated in angiogeneis?

Answer 8

VEGF and NOTCH signalling.

Question 9

Men 1 is what?

Question 10

Men 2A is what?

Question 11

Men2B is what?

Question 12

SCC in lung causes what paraneoplastic syndromes?

Answer 12

PTHrP and hypercalcaemia
Pancoast syndrome

Question 13

SCLC cauases what paraneoplastic?

Answer 13

Lambert eatan
SIADHA

Question 14

What is the gene affected in Marfan’s?

Answer 14

Fibrillin

Question 15

What causes pigmentation of cells in the spleen in patients with malaria?

Answer 15

Hemozin - digested heme eaten by the the parasite

Question 16

Are there fibroblasts in the brain?

Answer 16

No

Question 17

If there are no fibroblasts in the brain, then what fills damaged tissue after say a stroke?

Answer 17

Glial cells. Difficult to distinguish from tumour.

Question 18

What is sirtuin 1?

Answer 18

Its a protein that is released during intermittent fasting that is great. Reduces adipose tissue, makes you live longer.