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Heme > Random heme facts > Flashcards

Random heme facts Flashcards

0
Q

Where is B12 absorbed?

A

Ileum

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1
Q

Where is folate absorbed?

A

Jejunum

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2
Q

hematocrit

A

the ratio of packed red cells to total blood volume

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3
Q

MCV

A

mean cell volume: average volume of red cells

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4
Q

MCH

A

mean cell hemoglobin: the average hemoglobin content of per red cells

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5
Q

RDW

A

Red cell distribution width

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6
Q

clinical features of extravascular hemolysis

A

anemia, splenomegaly, jaundice

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7
Q

features of intravascular hemolysis

A

anemia, hemoglobinemia, hemoglobinuria, hemosiderinuria, jaundice

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8
Q

Heinz bodies

A

precipitated B globin chains

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9
Q

Howell Jolly bodies

A

small nuclear reminants

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10
Q

Paroxysmal Nocural hemoglobinuria can lead to what diseases?

A

Acuter myeloid leukemia or a myelodysplastic syndrome

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11
Q

blood smear findings of Megaloblastic anemia

A

macrocytic, oval cells, with possible hyperchromic cells. aniscytosis, poikilocytosis. hypersegmented neutrophils

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12
Q

Where is Iron absorbed?

A

Duodenum

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13
Q

What is the most common form of congenital sideroblastic anemia?

A

ALAS defect

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14
Q

Acquired Sideroblastic anemia

A

Alcohol, Vitamin B6 deficiency, lead poisoning

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15
Q

How does vitamin B6 cause anemia

A

required cofactor for ALAS enzyme in protoporphyrin synthesis.

16
Q

hematologic malignacy

A

abnormal proliferation of cells normally found in blood, bone marrow or lymph tissues

17
Q

leukemia

A

malignancy only involving bone marrow or bloodstream

18
Q

lymphoma

A

malignancy only involving lymphatic tissue

19
Q

Auer rods

A

needle like, red crystals formed by proteins. diagnostic of myeloid blasts

20
Q

what is a weak point of flow cytometry?

A

red cell precursors are under-represented due to the red cell lysis procedure

21
Q

DKK1

A

Produced by multiple myeloma cells. Leads to increase of RANKL and IL6 by. Osteoblast precursors and marrow stromal cells

Osteoclast maturation stimulated

Heme (5 decks)

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