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RUSVM Virology > Random Final Exam Questions > Flashcards

Random Final Exam Questions Flashcards

1
Q

Measles virus is used to protect puppies against canine distemper. This is possible becasue of antigenic similarity of their:

A

fusion [F] protein

p 186

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2
Q

T/F: There is significant cross-protection among the different serotypes of Vesicular Stomatitis

A

False.

There are 2 serotypes and several subtypes of vesiculovirus. There is no cross-protection among the serotypes

p 168

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3
Q

The Coggins test is used in detecting horses with:

A

equine infectious anemia

p. 160

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4
Q

T/F: Adenoviridae virions agglutinate RBCs

A

True

p 141

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5
Q

Which species is known to be resistant to Infectious Canine Hepatitis, but susceptible to Canine Distemper?

A

Ferrets!

p 143

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6
Q

Corneal edema [blue eye] occurs in most cases of Infectious Canine Hepatitis [ICH]

A

False

Corneal edema occurs in about 20% of natural infections and less than 1% of dogs after vaccination

p 144

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7
Q

T/F: Most Infectious Canine Hepatitis infections are asymptomatic

A

True

p 144

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8
Q

Which breed is said to be especially susceptible to Equine Adenovirus Infection? Why?

A

Arabian Foals

Arabian foals are known to be very susceptible due to their combined T and B cell immunodeficiency

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9
Q

Describe the inclusion bodies associated with Retroviruses

A

There are no inclusion bodies. So you would just be explaining nothing.

What a waste of time.

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10
Q

T/F: Endogenous Retroviruses are pathogenic retroviruses that occur widely in the genome of vertebrates

A

False

Endogenous Retroviruses are non-pathogenic retroviruses that occur widely in the genome of vertebrates

p 148

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11
Q

Fading kitten syndrome is associated with viremic queens infected with:

A

feline leukemia virus

p 156

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12
Q

The ELISA test for feline leukemia detects the presence of:

A

circulating p27 antigen in plasma

p27 protein is the mjor feline leukemia virus [FeLV] group-specific antigen. It is produced within virus infected leukocytes and platelets

p 152, 156

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13
Q

Which porcine disease is commonly associated with splenic infarcts and button ulcers in the colon?

A

Hog cholera

p 226

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14
Q

T/F: The disease of Maedi/Visna has been reported in sheep, cattle and swine.

A

False

Maedi/Visna is a disease of adult sheep and, to some extent, goats.

p 162

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15
Q

T/F: Incubation period of rabies is influenced by the distance the virus has to travel from its port of entry to the CNS.

A

True

p 167

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16
Q

T/F: A property of a virus belonging to the family paramyxoviridae is their ability to hemagglutinate RBCs in vitro.

A

True

p 178

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17
Q

T/F: Recovery from feline calicivirus infection is marked by intermittent shedding of virus for a period of time

A

True

p 240

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18
Q

T/F: A virus causing hog cholera can be identified in the lab using hemadsorption-inhibition assay

A

False

Diagnostic tests include virus isolation, antigen detection (FA or immunoperoxidase staining, ELISA), or serology

p 226

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19
Q

T/F: In feline immunodeficiency disease, the virus is shed mainly in saliva and principle mode of transmission is bites

A

True

p 157

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20
Q

T/F: Depopulation, a disease control measure, involves the culling of diseased animals only

A

False

Depopulation is the elimination of all susceptible hosts (infected, potentially infected, or contact animals) of a herd/flock or area basis

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21
Q

T/F: Regarding infectious canine hepatitis, the threshold antibody titer has been determined to be 1:100

A

False

1:500

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22
Q

T/F: Immunosuppression is a common sequela in diseases characterized by leukocytosis

A

False

Leukocytosis is a transient increase in the number of leukocytes in the blood

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23
Q

T/F: Antiretroviral protease inhibitors prevent the transcription of retroviral RNA into DNA genome

A

False

They inhibit viral proteases responsible for the cleavage of viral polyproteins into functional proteins by binding to their active sites

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24
Q

T/F: Corneal edema (blue eye), observed in some puppies presenting with infectious canine hepatitis, is an immune complex-mediated disease

A

True

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25
Q

T/F: Mammalian influenza virus is restricted to respiratory tract epithelial cells

A

True

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26
Q

T/F: BVD-MD is a cytopathic and non-cytopathic co-infection

A

True

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27
Q

T/F: Valtrex cannot be used to treat a herpesvirus infection caused by a herpesvirus with mutation in its thymidine kinase gene

A

True

Acyclovir requires the herpesvirus-specified enzyme, thymidine kinase, to phosphorylate it to acyclovir monophosphate.

p 76

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28
Q

T/F: Acute and convalescent serum samples for titration of antigen specific antibody titers are collected two to four weeks apart

A

True

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29
Q

T/F: After virus penetration into host cell, the parental RNA genome of a retrovirus is copied by reverse transcriptase into double-stranded DNA; this change in chromosome takes place in the nucleus of the host cell

A

False

Viral RNA is released into the cytoplasm. Parental RNA is copied to ssDNA by reverse transcriptase. ssDNA is made double-stranded, again by reverse transcriptase. dsDNA moves into the nucleus

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30
Q

T/F: The hemadsorption-inhibiting assay is always carried out using virus-infected cell culture

A

True

p 88

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31
Q

T/F: The antiretroviral drug AZT (zidovudine) prevents insertion of retroviral DNA into the host genome by binding to the active site of the viral integrase

A

False

AZT inhibits viral reverse transcriptase as well as causing chain termination, hence blocking the synthesis of proviral DNA

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32
Q

T/F: Azidothymidine (AZT), an antiviral drug, inhibits replication of feline immunodeficiency virus by inactivating the viral enzyme that cleaves polyproteins into functional proteins

A

True

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33
Q

T/F: Azidothymidine (AZT) is a nucleoside analog used in the treatment of AIDS and feline immunodeficiency disease. A nucleoside is a nucleotide minus a phosphate.

A

True

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34
Q

T/F: Phosphorylated azidothymidine (AZT) acts as a chain terminator if incorporated in to DNA, blocking the synthesis of proviral DNA.

A

True

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35
Q

T/F: Viruses that frequently undergo antigenic variation are usually associated with persistent infections

A

True

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36
Q

T/F: Type I and II interferons enhance cellular expression of MHC class I proteins.

A

True

37
Q

T/F: Bovine leukemia is characterized by the transformation of mainly T-lymphocytes

A

False

The major target cells are B-lymphocytes

38
Q

T/F: Cross-neutralization and cross-protection occur among the subgroups of feline leukemia virus

A

False

Neutralizing antibodies against gp70 proteins protect against viremia; the antibodies are subgroup specific

39
Q

Concernin calicivirus in cats, which statement is least accurate?

  • A. Recovered cats may shed virus for several months.
  • B. Protection against the disease is afforded through vaccination.
  • C. May be seen as conjunctivitis and pneumonia.
  • D. May result in corneal ulceration
A

D. May result in corneal ulceration

40
Q

T/F: Swine influenza belongs to the influenza B group

A

False

Influenza A virus subtypes H1N1, H1N3, H3N2

p 194

41
Q

Which is the most virulent type of Equine Encephalitis?

A

Eastern Equine Encephalitis

90-98% fatality

p 216

42
Q

T/F: Canine distemper is readily isolated from cell cultures

A

False

43
Q

What is the principal mode of infection for Feline Immunodeficiency Disease?

A

Cat bites

Virus is shed in saliva. Disease is most common in free-roaming cats. One bite is sufficient to transmit the virus

p 158

44
Q

Hyperkeratosis of the foot pad in dogs is sometimes associated with:

A

Canine Distemper

Also known as ‘hardpad disease’

p 185

45
Q

Bovine Ephemeral Fever is commonly seen in the northeastern United States

A

False

It is seen throughout Adrica, Middle East, Asia, & Australia. BEF has never been reported in the USA

p. 169

46
Q

T/F: Foot and Mouth disease is exotic to the US

A

True

47
Q

The virus responsible for Canine Influenza is a mutated strain of equine influenza virus

A

True

p 193

48
Q

T/F: Maedi/Visna Disease is associated with lifelong lymphocyte-associated viremia

A

True

49
Q

T/F: Lentiviruses are oncogenic

A

False

50
Q

Which of the following infects T lymphocytes?

  • a) Bovine Leukemia
  • b) Feline Leukemia and sarcoma
  • c) Avianleukosis
  • d) Sporadic Bovine Leukosis
A

**b) Feline Leukemia and sarcoma **

51
Q

Which of the following can be transmitted from cat to cat?

  • a) FeLV-A
  • b) FeLV-B
  • c) FeLV-C
  • d) a) and b)
  • e) a) and c)
A

d) FeLV-A and FeLV-B

52
Q

T/F: Caprine arthritis-encephalomyelitis causes hard bag, interstitial pneumonia, encephalitis and most commonly arthritis

A

True

53
Q

T/F: Maedi is a CNS disease and Visna is a respiratory disease

A

False

  • Visna is a CNS disease*
  • Maedi is a respiratory disease *
54
Q

T/F: Lentiviruses cause lifelong infections

A

True

55
Q

This is a cat

A

This is also a cat

56
Q

T/F: Bluetongue is a non-contagious disease

A

True

It is REPORTABLE though! WHAT WHAT

57
Q

How is Bluetongue transmitted (primarily)?

A

Arthropod vector (Culicoides)

58
Q

Which viral genus is the major cause of enteritis involving the small intestine in neonates of all domestic animals?

A

Rotavirus!

59
Q

Which of the following is not a reportable disease?

  • a) Blue tongue
  • b) Rotavirus infection
  • c) African Horse Sickness
  • d) EEEV, WEEV, VEEV
A

**d) EEEV, WEEV, VEEV **

60
Q

Reservoir for African Horse Sickness:

  • a) Horses
  • b) Zebras
  • c) Donkeys
  • d) Mules
  • e) dogs
A

**b) Zebras **

61
Q

T/F: Dunkop (acute/pulmonary) and Dikkop (subacute/cardiac) are the two common clinical forms of African Swine Fever

A

False

They are the 2 clinical forms of African Horse Sickness

62
Q

T/F: Group A rotaviruses are the major cause of severe diarrhea in young mammals and birds. This virus destroys the cells of the large intestine causing malabsorption and fluid secretion

A

False!

Destroys cells of the small intestine, not large

63
Q

T/F: Transmissible Gastroenteritis in pigs is a disease causing diarrhea and high mortality in piglets. Because of its impact on production, this disease is a List A disease

A

False

List B disease

64
Q

T/F: The virulent form of the Feline Infectious Peritonitis virus comes from a mutation of the enteric form. This new virus has a high tropism for macrophages

A

True

65
Q

Which of the following associations is true regarding the reservoir or amplifying host?

  • a) EEEV – equines
  • b) WEEV – equines
  • c) VEEV enzootic cycle – equines
  • d) VEEV epizootic cycle - equines
A

**d) VEEV epizootic cycle - equines **

66
Q

At what stage of gestation will a calf become a persistent carrier if the cow gets infected with bovine viral diarrhea?

  • a) <1 month
  • b) 2-4 months
  • c) 5-9 months
  • d) 9 months
A

**b) 2-4 months **

67
Q

T/F: A calf with the noncytopathic form of bovine viral diarrhea will have an uncleaved NS2-3 protein, be a persistent carrier of the disease and will show symptoms such as poor weight gain, diarrhea and mucosal disease.

A

True

68
Q

T/F: Hog cholera or classical swine fever is characterized by turkey egg kidneys and a button ulcer colon

A

True

69
Q

Lesions observed in infectious canine hepatitis are a consequence of virus replication in the following cells except:

  • Vascular endothelium
  • Hepatocytes
  • Neurons
  • Kupffer cells
A

Neurons

70
Q

The main targets for ICH’s viremia phase are all of the following except:

  • Kidneys
  • Liver
  • Lungs
  • Pancreas
  • Spleen
A

Pancreas

71
Q

T/F: Environmental decontamination with a lipid solvent will inactivate adenoviruses

A

True

72
Q

T/F: Rubarth’s disease only infects bears and domestic dogs

A

False

Also wild dogs. Remember fox encephalitis

73
Q

Regarding retroviruses: What does the gag gene encode for?

A

capsid

74
Q

T/F: Most kittens born to a viremic queen become viremic and die. This is known as Fading Kitten Syndrome, and it is a neoplastic disease

A

False

Fading Kitten Syndrome is non-neoplastic

75
Q

Replication of bovine ephemerovirus occurs in all of the following except:

  • Monocytes
  • Splenic Macrophages
  • Pulmonary Macrophages
  • Kupffer Cells
  • Lymph Node Macrophages
A

Lymph Node Macrophages

76
Q

T/F: Bats account for most cases of rabies in cattle

A

False

Skunks, not bats

77
Q

Foot & Mouth Disease causes abortion because the virus crosses the placenta.

A

False

Abortions due to fever/dehydration

78
Q

T/F: Picornoviruses are the largest of the RNA viruses, and do not form inclusion bodies

A

False

Picornoviruses are the smallest of the RNA viruses, and do not form inclusion bodies

79
Q

All of the following hemagglutinate except:

  • Canine Distemper
  • Canine Parainfluenza virus 5
  • Newcastle Disease
  • Bovine Respiratory Syncytial Disease
A

Bovine Respiratory Syncytial Disease

80
Q

An incorrect statement concerning avian influenza is

  • Wild ducks and other waterfowl serve as natural reservoirs
  • Protection is afforded through vaccination
  • Lesions may be observed in the GIT and respiratory tract
  • Currently the virus causing disease in the USA is subtype H5N2
A

Wild ducks and other waterfowl serve as natural reservoirs

81
Q

T/F: While influenza viruses in birds are contained in the respiratory tract, influenza in mammals is systemic and affects the respiratory tract, GIT and CNS, and is deadly

A

False

While influenza viruses in mammals are contained in the respiratory tract, *influenza in birds is systemic and affects the respiratory tract, GIT and CNS, and is deadly. *

82
Q

T/F: Antigenic shift results in a major antigenic change, while antigenic drift results in a minor change and involves point mutations.

A

True

83
Q

Infectious canine hepatitis is characterized by virus replication in each of the cells listed below except:

  • Endothelial cells
  • Erythrocytes
  • Hepatocytes
  • Kuppfer cells
A

Erythrocytes

84
Q

What would be the drug of choice for reversal of a neuromuscular blockade by rocuronium?

A

Sugammadex

85
Q

T/F: Mastadenoviruses are bifurcated, giving the appearance of two fibers extending from each penton base

A

False

Aviadenoviruses are bifurcated, not mastadenoviruses

86
Q

Tumor-specific antigen present only on the membrane of cells transformed by either FeLV or FeSV:

A

FOCMA

87
Q

Concerning equine infectious anemia, which statement is least accurate?

  • The virus is transmitted by mosquitoes and horseflies
  • Lifelong, irreversible viremia occurs in infected horses
  • The virus multiplies in erythrocytes and causes anemia by intravascular hemolysis
  • Antigenic variation is a hallmark of the equine infectious anemia virus
A

The virus multiplies in erythrocytes and causes anemia by intravascular hemolysis

The virus replicates in MACROPHAGES and then in lymphocytes

88
Q

Vaccination has been a critical factor in reducing the incidence of the following diseases in domestic animals except?

  • Feline rhinotracheitis
  • Infectious laryngotracheitis
  • Sheeppox
  • Equine infectious anemia
A

Equine infectious anemia

RUSVM Virology (4 decks)

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