random facts etc.

Question 1

what is tachyphylaxis

Answer 1

decrease in response after repeated administrations

Question 2

which permeate membranes better unionised/ionised

Answer 2

Unionised

Question 3

first-order elimination

Answer 3

constant fraction removes (exponential)

Question 4

zero order elimination

Answer 4

constant amount (linear)

Question 5

Ka

Answer 5

affiniteitsconstante = concentratie waarbij de helft vd receptoren bezet is

Question 6

CYP enzymen geassocieerd met welke fase reactie?

Answer 6

Fase 1

Question 7

stereospecificity

Answer 7

the 3-dimensional fit of a ligand in the binding pocket of the receptor and can be different as a result of asymmetry

Question 8

4 volumes of distribution

Answer 8

plasma (smallest),
interstitial fluid,
intracellular fluid,
fat tissue

Question 9

pharmacokinetics

Answer 9

what the body does to the drug

Question 10

pharmacodynamics

Answer 10

what the drug does to the body

Question 11

Ehrlic’s principle

Answer 11

zonder binding van ligand is er geen effect

Question 12

Therapeutic index

Answer 12

TD50/ED50 (hoog TI is gewenst)

Question 13

opties voor interventie (bv bij serotonine)

Answer 13

interventie bij synthese
interventie bij receptor actie
interventie bij breakdown

Question 14

wat is P-glycoproteine

Answer 14

pomp die constant toxische stoffen naar buiten pompt

Question 15

renale excretie

Answer 15

1. glomerulaire filtratie (mol. gew. minder dan 60kD)
2. actieve tubulaire secretie (alleen niet eiwitgebonden)
3. tubulaire reabsorptie (concentratie en polariteit gebonden)

Question 16

Fase I metabolisme

Answer 16

bio-activatie of bio-inactivatie via polaire groep

Question 17

Fase II metabolisme

Answer 17

zuurgroep gekoppeld –> hydrofiel molecuul met verminderde activiteit ontstaat