Random Drugs

Question 1

Tetrabenzine

Reserpine

Answer 1

Inhibit VMAT dopamine - decreased packaging and release

Question 2

Local anesthetic that causes…

1. severe cardiovascular toxicity
2. Methemoglobinemia

Answer 2

Bupivacaine

benzocaine

Question 3

Local anesthetics

Answer 3

*Block Na+ channels by binding to specific receptors on inner portion of the channel - most effective in rapidly firing neurons
Ester vs. aminde
*Alkaline anesthetics are charged in acidic/infected tissue - cannot penetrate membrane thus must increase dose
Blockade: small>large myelinated >small >large unmyelinated

Question 4

Cyclobenzaprine

Answer 4

skeletal muscle relaxant, acts within CNS

Question 5

Pentazocine

Answer 5

k-opioid receptor agonist and u-opioid receptor partial agonist

• analgesia for moderate to severe pain
• can precipitate withdrawal

Question 6

Butorphanol

Answer 6

k-opioid receptor agonist, u-receptor partial agonist

• severe pain
• can precipitate withdrawal

Question 7

Hyoscyamine

Answer 7

Muscarinic antagonist - antispasmodic for IBS

Question 8

Dicyclomine

Answer 8

Muscarinic antagonist - antispasmodic for IBS

Question 9

Ranolazine

Answer 9

inhibits late phase of sodium current - reducing diastolic wall tension and O2 consumption
*Angina refractory to other medical therapies

Question 10

Ivabradine

Answer 10

Selective inhibition of funny sodium channels (If) - prolonging slow depolarization phase, Decreased SA node firing negative chonotropic effect without inotropy
*Chronic stable angina in patients who cannot take beta-blockers