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USMLE Step 1 > Oncogenes/Tumor Suppresors > Flashcards

Oncogenes/Tumor Suppresors Flashcards

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USMLE® Step 1 flashcards
1
Q

ALK

A

Oncogene
Tyrosine kinase
Lung adenocarcinoma

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2
Q

BCR-ABL

A

Oncogene
Tyrosine kinase
CML, ALL

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3
Q

BCL-2

A

Oncogene
Anti-apoptotic
Follicular and tissue large B cell lymphoma

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4
Q

BRAF

A

Oncogene
Serine/threonine kinase
Melanoma non-Hodgkin lymphoma, papillary thyroid cancer

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5
Q

c-Kit

A

Oncogene
cytokine receptor
Gastrointestinal stromal tumor

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6
Q

c-Myc

A

Oncogene
Transcription factor
Burkitt lymphoma

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7
Q

Her2/neu (c-ERB2)

A

Oncogene
Receptor tyrosine kinase
Breast and gastric cancer

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8
Q

Jak2

A

Oncogene
Tyrosine kinase
Chronic myeloproliferative disorders

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9
Q

KRAS

A

Oncogene
GTPase
Colon cancer, lung cancer, pancreatic cancer

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10
Q

MYLC1

A

Oncogene
Transcription factor
Lung tumor

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11
Q

N-myc

A

Oncogene
Transcription factor
Neuroblastoma

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12
Q

RET

A

Oncogene
Receptor tyrosine kinase
MEN 2A, 2B, papillary thyroid cancer

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13
Q

APC

A

Tumor suppressor
Negative regulator of beta-catenin/WNT pathway
Colorectal cancer

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14
Q

BRCA

A

Tumor suppressor
DNA repair protein (homologous recombination)
Breast, ovarian, pancreatic cancer

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15
Q

CDKN2A

A

Tumor suppressor
p16, blocks G1 –> S transition
Melanoma, pancreatic

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16
Q

Rb

A

Tumor suppressor
Inhibits E2F - blocks G1 –> S transition
Retinoblastoma, osteosarcoma

17
Q

Psammoma bodies

A

Papillary thyroid cancer
Serous cystoadenocarcinoma of ovary
Meningioma
Malignant mesothelioma

18
Q

Elevated AFP

A 
HCC
Neural tube defects 
Endodermal sinus tumor 
Mixed germ cell tumor 
Ataxia-telengectasia 
[Low AFP - Down Syndrome]
19
Q

CA 15-3/CA 27-20

A

Breast cancer

20
Q

CEA

A

Colorectal, pancreatic cancer

21
Q

S-100 Stain

A

Neural crest origin

Melanoma, schwannoma, Langhernas cell histiocytosis

22
Q

Neurofilament

A

Neurons

23
Q

Chromogranin and synaptophysin

A

Neuroendocrine cells

24
Q

Desmin

A

muscle tumors

25
Q

Vimentin

A

Mesenchymal

USMLE Step 1 (4 decks)

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