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What does Cushing’s triad (reflex) consist of?
- Irregular respiratory rate
- Hypertension
- Bradycardia
It is a physiological response to raised intra-cranial pressure
What is Beck’s triad?
Three medical signs associated with cardiac tamponade:
- Arterial hypotension
- Distended neck veins
- Muffled heart sounds
What is Virchows triad?
Factors that contribute to thrombosis:
- Stasis of blood flow
- Hypercoagulability
- Endothelial injury
What is Charcot’s triad?
Refers to cholangitis:
- Jaundice
- Fever (usually with rigors)
- Right upper quadrant abdo pain
On an X-ray, what condition is an ‘onion skin pattern’ characteristic of?
Ewings sarcoma
On an X-ray, what condition is a ‘sunburst lesion’ characteristic of?
Osteosarcoma
What is Takotsubo cardiomyopathy?
AKA stress cardiomyopathy, broken heart syndrome or octopus pot cardiomyopathy, is a non-ischaemic cardiomyopathy whereby there is a sudden and temporary weakening of the ventricle which often mimics an acute coronary syndrome
What are the cytochrome P450 inducers? (5)
- Carbamazepine
- Rifampicin
- Barbituates
- Phenytoin
- St. Johns wort
What are the cytochrome P450 inhibitors? (9)
- Sodium valproate
- Ciprofloxacin
- Sulphonamide
- Cimetidine/omeprazole
- Anti-fungals
- Amiodarone
- Isoniazid
- Erythromycin/clarithromycin
- Grapefruit juice
Which drugs interact with the cytochrome P450 inhibitors/inducers?
Warfarn COCP Theophylline Corticosteroids Tricyclics Pethidine Statins