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Question 1

Drug given to breast Cancer to prevent conversion of androstenedione to estrogen

Answer 1

Anastrozole

Question 2

careful evaluation of the dose-response relationship and
pharmacokinetics among normal human volunteers
25–100
acute effects

Answer 2

PHASE 1 TRIAL

Question 3

determine whether the agent has the desired efficacy at doses
that are tolerated by sick patients
100-200 patients

Answer 3

PHASE 2 TRIAL

Question 4

special population” (1000–5000)
compare it with older therapies, and to discover
infrequent toxicities not seen in Phase 2

Answer 4

PHASE 3 TRIAL