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Pharma PLE2020 > Autonomic Pharma > Flashcards

Autonomic Pharma Flashcards

1
Q

Inhibits acetylcholinesterase (AChE)

A

Carbamates & Organophosphates

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2
Q

resistant to hydrolysis of AChE

A

carbachol and bethanechol

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3
Q

facilitate aqueous humor outflow and diminish its rate of secretion

Glaucoma, Sjögren syndrome, Sicca syndrome

A

PILOCARPINE

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4
Q

Sjögren Syndrome triad

A
  • Xerostomia (Dry Mouth)
  • Xerophthalmia (Dry Eyes)
  • Rheumatoid Arthritis
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5
Q

DOA of EDROPHONIUM

A

5-15min

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6
Q

Antidote for organophosphate poisoning (first choice)

A

ATROPINE

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7
Q

Muscarinic Antagonists for Parkinsonism

A
  • TRIhexyphenidyl
  • BENZtropine
  • BIPeriden
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8
Q

may be used as a monotherapy as maintenance for COPD

A

Glycopyrronium

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9
Q

highest propensity to cause CNS symptoms compared to all the other anticholinergics

CENTRAL ANTICHOLINERGIC SYNDROME

A

SCOPOLAMINE

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10
Q

Reduces Detrusor muscle tone

For Urge incontinence, Post-operative spasms

A

OXYBUTYNIN

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11
Q

Arrhythmias seen in ATROPINE TOXICITY

A

intraventricular conduction block

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12
Q

inhibits entry of calcium triggers interaction among SNARE proteins (VAMPs and SNAPs)

A

Guanethidine

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13
Q

promotes entry of calcium triggers interaction among SNARE proteins (VAMPs and SNAPs)

A

Amphetamines and Tyramine

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14
Q

inhibits diffusion and reuptake via NET and DAT in synaptic cleft

A

Cocaine and TCAs

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15
Q

stimulates lipolysis

A

Beta3

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16
Q

First line treatment for refractory hypotension in

severe sepsis, Cardiogenic shock (last resort)

A

NOREPINEPHRINE

17
Q

DOSE-DEPENDENT ACTIONS OF DOPAMINE

A 
LOW DOSE (0.5 to 3 mcg/kg/min)
o Stimulates D1 and D2 receptors -vasoD
MEDIUM DOSE (3-10 mcg/kg/min)
o Stimulates β1 receptors
HIGH DOSE (>10 mcg/kg/min)
o Stimulates α1 receptors - vasoC
18
Q

DOC for Alpha-1 agonist overdose

A

Phentolamine

19
Q

Pseudoephedrine in the 1st trimester causes

A

gastroschisis

20
Q

Conscious sedation

A

Dexmedetomidine

21
Q

most common undesirable SE of METHYLDOPA

A

Sedation

22
Q

Eosinophilic myocarditis

A

DOBUTAMINE

23
Q

Irreversibly blocks a adrenergic receptors (a1>a2) by
forming a covalent bond with the receptors

Pheochromocytoma (pre-surgical)

A

PHENOXYBENZAMINE

24
Q

Increases outflow through canal of Schlemm

A

Latanoprost,

Brimatoprost

Pharma PLE2020 (3 decks)

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