Autonomic Pharma Flashcards
Inhibits acetylcholinesterase (AChE)
Carbamates & Organophosphates
resistant to hydrolysis of AChE
carbachol and bethanechol
facilitate aqueous humor outflow and diminish its rate of secretion
Glaucoma, Sjögren syndrome, Sicca syndrome
PILOCARPINE
Sjögren Syndrome triad
- Xerostomia (Dry Mouth)
- Xerophthalmia (Dry Eyes)
- Rheumatoid Arthritis
DOA of EDROPHONIUM
5-15min
Antidote for organophosphate poisoning (first choice)
ATROPINE
Muscarinic Antagonists for Parkinsonism
- TRIhexyphenidyl
- BENZtropine
- BIPeriden
may be used as a monotherapy as maintenance for COPD
Glycopyrronium
highest propensity to cause CNS symptoms compared to all the other anticholinergics
CENTRAL ANTICHOLINERGIC SYNDROME
SCOPOLAMINE
Reduces Detrusor muscle tone
For Urge incontinence, Post-operative spasms
OXYBUTYNIN
Arrhythmias seen in ATROPINE TOXICITY
intraventricular conduction block
inhibits entry of calcium triggers interaction among SNARE proteins (VAMPs and SNAPs)
Guanethidine
promotes entry of calcium triggers interaction among SNARE proteins (VAMPs and SNAPs)
Amphetamines and Tyramine
inhibits diffusion and reuptake via NET and DAT in synaptic cleft
Cocaine and TCAs
stimulates lipolysis
Beta3
First line treatment for refractory hypotension in
severe sepsis, Cardiogenic shock (last resort)
NOREPINEPHRINE
DOSE-DEPENDENT ACTIONS OF DOPAMINE
LOW DOSE (0.5 to 3 mcg/kg/min) o Stimulates D1 and D2 receptors -vasoD
MEDIUM DOSE (3-10 mcg/kg/min) o Stimulates β1 receptors
HIGH DOSE (>10 mcg/kg/min) o Stimulates α1 receptors - vasoC
DOC for Alpha-1 agonist overdose
Phentolamine
Pseudoephedrine in the 1st trimester causes
gastroschisis
Conscious sedation
Dexmedetomidine
most common undesirable SE of METHYLDOPA
Sedation
Eosinophilic myocarditis
DOBUTAMINE
Irreversibly blocks a adrenergic receptors (a1>a2) by
forming a covalent bond with the receptors
Pheochromocytoma (pre-surgical)
PHENOXYBENZAMINE
Increases outflow through canal of Schlemm
Latanoprost,
Brimatoprost
