Random 3 Flashcards

1
Q

How do you diagnose, investigate and manage IUGR?

A

Diagnosis: fetal abdominal circumference/estimated fetal weight <10th centile

Investigations: serial ultrasound measurements, uterine artery doppler from 26-28 weeks

Management: aspirin before 16 weeks, progesterone therapy to prevent preterm birth
if detected preterm, deliver at 32 weeks
if detected after 32 weeks, deliver at 37 weeks

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2
Q

What are the investigations of prematurity?

A

For women with intact membranes >30w

  • TVS (cervical length)
  • Fetal fibronectin
  • Vaginal swab
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3
Q

What is the management of prematurity?

A

Tocolytic drugs (nifedipine or terbutaline)

Corticosteroids (if between 24-35 weeks)

Magnesium sulfate (4g for neuroprotection, give to women between 24-29 weeks or 30-33 weeks)

Emergency cleavage: women between 16-34 weeks with a dilated cervix and unruptured exposed membranes

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4
Q

What are red flags that can occur in a sick or deteriorating pregnant patient?

A
Pyrexia >38, RR >20
Breathlessness 
Headache
Abdominal pain/diarrhoea 
Anxiety/distress
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5
Q

What management would you do for a sick or deteriorating pregnant patient?

A
Call for senior help
Increase observation frequency
Left lateral tilt, CTG
Check IV lines, drug chart 
ECG/ABG/Venepuncture
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6
Q

What are the risk factors, diagnosis, management, and screening for gestational diabetes?

A

RF: Afro-Caribbean, BMI >30, previous GD, previous macrosomic baby, family history

Diagnosis: fasting >5.6, 2 hour >7.8

Screening: women who have had previous GD = OGTT 75mg at booking and 24-28 weeks

Management: if fasting <7 = trial of diet and exercise, if this fails, metformin. if fasting >7 = single injection intermediate insulin (e.g. isophane)
if this still does not work = add short acting insulin before meals

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7
Q

What are the complications of pre-existing diabetes in pregnancy?

A
Miscarriage
Pre-eclampsia 
Preterm labour 
Stillbirth 
Congenital malformations
Macrosomia 
Birth injury 
Hypoglycaemia
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8
Q

What is the pre-conception care of diabetes?

A

Avoid unplanned pregnancies
Keep HbA1c <48 (6.5%)
BMI >27 = lose weight
Take 5mg of folic acid until 12w

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9
Q

What is the management/targets of diabetes in pregnancy?

A

Stop medications apart from metformin
Folic acid

Fasting: 5.3
1 hour PP: 7.8
2 hour PP: 6.4

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10
Q

If a baby is born hypoglycaemic, what do you give it?

A

IV dextrose

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11
Q

What is the management for women who are at a high risk of developing pre-eclampsia?

A

Take 75mg aspirin from 12w until birth

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12
Q

What are the high risk groups of getting hypertension in pregnancy?

A

HTN in previous pregnancies
CKD
Autoimmune disorders
Diabetes

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13
Q

How does BP change physiologically in a normal pregnancy?

A

BP decreases in first trimester, falls until 20-24 weeks then rises back up again

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14
Q

What is the management of pre-existing hypertension before pregnancy?

A

Keep BP below 150/100mmHg
Regularly test for proteinuria
A BP of >140/90mmHg before 20 weeks is diagnostic for pre-existing hypertension

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15
Q

How do you diagnose gestational hypertension?

What is the diagnostic criteria of mild, moderate and severe HTN and what is the management for each?

A

Hypertension occurring after 20 weeks
Mild: 140-149/90-99: measure BP twice weekly, check for proteinuria
Moderate: 150-159/100-109: measure BP twice weekly, start labetolol, proteinuria tests
Severe: 160/110: admit to hospital, measure BP four times weekly, proteinuria checks daily

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16
Q

What is pre-eclampsia/eclampsia?

What can pre-eclampsia predispose you to?

A

HTN in pregnancy associated with proteinuria with/without oedema

prematurity/IUGR/eclampsia/haemorrhage/multi organ failure

17
Q

What are the high risk factors for pre-eclampsia?

A

HTN in previous pregnancy
CKD
Diabetes
Autoimmune disease

18
Q

What is the pathophysiology of pre-eclampsia?

A

Spiral arterioles fail to unfold (second trophoblastic phase failure) causing high placental pressure and reduced blood flow to the fetus.

Associated with a maternal inflammatory response/endothelial dysfunction

19
Q

What are the features of pre-eclampsia/eclampsia?

What are the features of severe eclampsia?

A

Pre-eclampsia: only have proteinuria and HTN
Eclampsia: all other symptoms

Severe: HTN >170/110, headache, visual disturbance, papilloedema, RUQ/epigastric pain, hyperreflexia

20
Q

What is the management of pre-eclampsia/eclampsia?

A

Oral labetalol if BP 150-159/100-109
Admit if increased BP with proteinuria
Monitor BP four times daily
If labetalol is CI give nifedipine or hydralazine
MgSO4 to control seizures: 4g then 1g/hour

21
Q

What is the management of epilepsy and pregnancy?

A

5mg folic acid per day during conception and first trimester
Continuous CTG in case of a seizure
Lorazepam/diazepam IV in case of a seizure

22
Q

What anti epileptics will fuck you up in pregnancy?

A

Sodium valproate = neural tube defects

Phenytoin = cleft lift palate (give vitamin K in the last month of pregnancy)

23
Q

What are the UKMEC guidelines for anti-epileptics and contraception?

A

For women taking phenytoin, carbamazepine, barbiturates primidone, topiramate
UKMEC3: COCP, POP
UKMEC2: Implant
UKMEC1: Depo-Provera, IUS, IUD

For women taking lamotrigine:
UKMEC3: COCP
UKMEC1: POP/implant/Depo/IUS/IUD

24
Q

What are the benefits of breast feeding?

A

decreased risk of cot death
decreased risk of breast and ovarian cancer and diabetes
boosts baby’s immunity to infection
increased intelligence

25
Q

What is a primary PPH?
What is a secondary PPH?

What are the causes of a secondary PPH?

A

1) loss of blood >500mL from genital tract <24h of delivery
2) abnormal bleeding from the genital tract from 24h to 6w

3) endometritis, retained products of conception

26
Q

what are the symptoms/signs of endometritis?

what is the management of it?

A

offensive lochia
suprapubic tenderness
abnormal vaginal discharge/bleeding
dyspareunia

IV pip/taz

27
Q

what is the management of retained products of conception?

A

elective curettage and antibiotics

28
Q

what three things can cause primary prevention of a PPH?

A

active management of third stage of labour
prophylactic oxytocin in third stage
syntometrine

29
Q

what are the four T’s (aetiology of PPH)?

A

tone (uterine atony, distended bladder)
trauma (lacerations)
tissue (retained placenta)
thrombin (coagulopathy)

30
Q

what is the emergency management of a PPH?

A

IV access, 14 gauge cannula, crystalloid infusion
IV syntocinon (oxytocin) or ergometrine
IM carboprost
surgical: 1) intrauterine balloon tamponade
B Lynch suture
ligation of the uterine arteries or internal iliac arteries

31
Q

Name three risks of breech presentation

A

Cord prolapse
Head entrapment
Fetal hypoxia

32
Q

Outline the procedure of external cephalic version

A

Offered at 36 weeks in nulliparous women and 37-38 weeks in multiparous women
Uterine relaxants are given pre/post procedure
CTG pre/post

May prevent C-section and breech
May cause fetal distress (cord entanglement etc)

33
Q

What are the causes of a transverse or oblique lie?

A
Fibroids
Septate or bicornuate uterus
Polyhydramnios 
Fetal abnormalities
Placenta praevia 
Twins
34
Q

What are the causes of a woman who is large for dates?

A

Macrosomia
Polyhydramnios (AFI >24cm)
Wrong dates

35
Q

What are the causes of polyhydramnios?

What are the risks of polyhydramnios?

A
'DITCH'
Diabetes
Idiopathic
Twins 
Congenital abnormalities
Heart failure 
Risks: PPPP
Postpartum haemorrhage
Placental abruption
Premature labour
Prolapse of cord
36
Q

What are the ‘pre-eclampsia bloods’?

A

FBC = low platelets
Low Hb = haemolysis in HELLP syndrome
U&E = raised urea and creatinine
LFT = raised ALT and AST