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Question 1

What risks do DES exposure cause

Answer 1

 Increased risk of breast cancer
 Vaginal and cervical clear cell adenocarcinoma
 CIN/VaIN
 Fertility and pregnancy problems
 Structural abnormalities of uterus
 T-shape, hypoplastic, endometrial adhesions
 PTB
 Miscarriage
 May have slightly earlier menopause
 Evidence of increased risk of cerebrovascular and cardiovascular disease.