Infertility Flashcards
Hyperprolactinaemia
Causes: Hypothalamic PRL stimulation e.g. primary hypothyroidism, adrenal insufficiency
Meds: dopamine antagonists, antipsychotics , CCB
Neurogenic: breast feeding, chest wall injury,
Increased production: PCOS, adenomas, hypothalamic stalk interuption, hypophysistis
Redcued elmintation: renal failure, hepatic insufficiency
Galactorrhoea
Amenorrhoea / oligo
Headache / neuro - rare
Disrupts normal pulsatile secretion of GnRH, altered LH and FSH secretion and impaired gonadal steroidogenesis –> infertility and gonadal dysfunction
Indirectly causes imbalance in lipis, osteoporosis, atrophic genitourinary system, increases ACTH and adrenal androgens, disturbs insulin secretion
POI –> prolactin causes destruction of ovarian follicles
Treatment: bromocriptine or cabergoline - restore ovulation in 90%
Surgical resection
RTX
