Raine et Al

Question 1

how many pp’s

Answer 1

• 41 people: 39M 2F
• charged with murder
• pleading not guilty by reason of insanity
• (NGRI)
• all referred for PET for legal reasons
• average age 34.3

Question 2

what were the medical histories of the pp’s

Answer 2

• schizophrenia 6
• head injury/organic brain damage 23
• drug abuse 3
• affective disorder 2
• epilepsy 2
• hyperactivity or learning disorder 3
• personality disorder 2

Question 3

what were the control group used to match ?

Answer 3

• 1 for each subject
• matched for age / sex
• schizophrenics with non-murderer
• schizophrenics
• all controls screened for mental/physical
• health

Question 4

explain how the Pet process occoured?

Answer 4

• injection with glucose tracer
• 32 mins on target recognition task
• NRGI/controls compared re 14 L&R brain
• areas
• 6 cortical:
• inc prefrontal; parietal; temporal
• 8 sub cortical:
• inc corpus callosum; amygdala; hippocampus

Question 5

what is ANOVA ?

Answer 5

• statistical comparison
• Analysis Of Variance
• compares a range of factors

Question 6

what are the results in the cortical areas?

Answer 6

• differences in activity in lobes of cerebral cortex cf controls;
• parietal & pre-fontal: less activity
• occipital: more activity
• temporal: same

Question 7

what are the results in the sub cortical areas?

Answer 7

• less activity in corpus callosum cf controls
• a sub-cortical area
• cf Sperry
sub cortical areas
• imbalance between hemispheres cf controls in;
• amygdala; hippocampus – less activity L / more R
• thalamus - more activity R / same L
• handedness made no difference
• ethnicity made no difference
• head injury patients’ corpus callosum only difference