Radiosensitivity

Question 1

Two french scientists of law of radio sensitivity

Answer 1

Bergonie and Tribondeau

Question 2

theorized and observed that radiosensitivity was
a function of the metabolic state of tissue being irradiated.

Answer 2

Bergonie and Tribondeau

Question 3

the law states that the
radiosensitivity of tissue varies within

Answer 3

maturation and metabolism

Question 4

The law has found some application in

Answer 4

Radiation oncology

Question 5

In 1906, radiologist Jean Alba Bergonie and physician Louis Tribondeau observed the effects of

Answer 5

radiation
by exposing rodent testicles to X-rays.

Question 6

Were selected because they contain both mature and immature cells

Answer 6

Testes

Question 7

Execute the organ’s principal function

Answer 7

Mature cells

Question 8

evolve into mature, functional cells.

Answer 8

Immature cells

Question 9

divide frequently,

Answer 9

Spermatogonia

Question 10

Cells do not divide

Answer 10

Spermatozoa

Question 11

After irradiating the testes, Bergonie & Tribondeau noticed the

Answer 11

immature cells were injured at lower doses than the mature cells.The immature cell

Question 12

Supported by their observations, they proposed a law describing
radiation sensitivity for all body cells which is the

Answer 12

Law of Bergonie Tribondeau.

Question 13

Their law maintains that actively mitotic and undifferentiated cells
are most susceptible to damage from ionizing radiation.

Answer 13

The Law of Bergonie and Tribondeau

Question 14

The Law of Bergonie and Tribondeau states that:

Answer 14

Stem or immature cells are more radio sensitive than mature cells.
Younger tissues and organs are more radio sensitive than older tissues and organs.
The higher the metabolic cell activity. The more radio sensitive it is.
The greater the proliferation and growth rate for tissues, the greater the radio sensitivity.

Question 15

In 1925, embryologists ____ and _____ modified the law of Bergonie and Tribondeau.

Answer 15

Paul Ancel and P. Vitemberger

Question 16

They suggested that the intrinsic susceptibility of
damage to any cell by ionizing radiation is identical, but that the timing of manifestation of radiation-produced damage varies according to the cell
type.

Answer 16

Paul Ancel and P. Vitemberger

Question 17

Their experiments on mammals demonstrated that there are two factors that affect the
manifestation of radiation damage to the cell:

Answer 17

1. The amount of biologic stress the cell receives.
2. Pre- and post-irradiation conditions to which the cell is exposed.