Radio Drugs Flashcards
What does a radio drug consist of ?
Vehicle + Radionuclide
What is the VEIHCLE in a radio drug ?
Non-radioactive substance
What is the function of the RADIONUCLIDE in the Radio drug ?
It’s the source of the radioactivity
What type of tracer is radiotracer that is concentrated only at the level of the lesion ?
Positive tracer
What is the distance that gamma particles travel ?
distance of mm, affect many cells
What is the distance that alpha/beta particles travel ?
distance of tens of fractions of mm, they affect few cells
example of positive tracer ?
FDG
example of negative tracer ?
Tc-99m
what IODINE radiotracer has longer half life ? (Iodine 131/ Iodine 123)
Iodine 131- 8 days !!!
compared to 13h of iodine-123
In what forms can Tc-99m be injected ?
- Sodium pertechnetate
- Labeled to organic molecules
what emission and half-life are preferred for the SPECT imaging ? (regarding radioisotopes)
Radioisotopes with ;
-Gamma emission
-Shorter half life
Sodium pertechnetate mimics ______
iodide ions
A SPECT scan is an imaging test that shows how
blood flows to tissues and organs.
what is the use of Tc99m-bisphosphonates ?
commonly used in bone scintigraphy
where do bispohosphonates accumulate ?
sites of bone mineral rearrangement
What is the most used PET radioisotope ?
FDG
main use of FDG ?
oncology
use of FDG in oncology allows us to do _______, ______, _______________
diagnosis
staging
response to tx
other uses of FDG other than oncology ?
Neurological disorders
Myocardial viability assessment
identify sites of inflammation
What particles are used in nuclear medicine for the purposes of therapy ?
Short range particles (alpha/beta)
Main indication of Samarium-153 ?
palliative tx of bone metastasis
What is the main indication for Radium-223 ?
Bone metastasis from Prostate cancer
What is the main indication of Lutetium 177 ?
NET
What type of images are produced from PET ?
3D
what is the most used radionuclide ?
Iodine 131
Except the thyroid, what other tissues can pick up the iodine 131?
Salivary glands and the gastric mucosa
99m Tc- Bisphosphonates are analogues of what ?
Pyrophosphate
What cells have an high uptake of 18F-FDG ?
cancer and inflammatory cells
What are the particles we find use in therapy ?
Alpha and Beta
Sestamibi as POSITIVE tracer detects ;
-Parathyroid adenomas or neoplastic
Sestamibi as NEGATIVE tracer detects ;
Myocardial perfusion
