Radio Drugs

Question 1

What does a radio drug consist of ?

Answer 1

Vehicle + Radionuclide

Question 2

What is the VEIHCLE in a radio drug ?

Answer 2

Non-radioactive substance

Question 3

What is the function of the RADIONUCLIDE in the Radio drug ?

Answer 3

It’s the source of the radioactivity

Question 4

What type of tracer is radiotracer that is concentrated only at the level of the lesion ?

Answer 4

Positive tracer

Question 5

What is the distance that gamma particles travel ?

Answer 5

distance of mm, affect many cells

Question 6

What is the distance that alpha/beta particles travel ?

Answer 6

distance of tens of fractions of mm, they affect few cells

Question 7

example of positive tracer ?

Answer 7

FDG

Question 8

example of negative tracer ?

Answer 8

Tc-99m

Question 9

what IODINE radiotracer has longer half life ? (Iodine 131/ Iodine 123)

Answer 9

Iodine 131- 8 days !!!

compared to 13h of iodine-123

Question 10

In what forms can Tc-99m be injected ?

Answer 10

1. Sodium pertechnetate
2. Labeled to organic molecules

Question 11

what emission and half-life are preferred for the SPECT imaging ? (regarding radioisotopes)

Answer 11

Radioisotopes with ;

-Gamma emission

-Shorter half life

Question 12

Sodium pertechnetate mimics ______

Answer 12

iodide ions

Question 13

A SPECT scan is an imaging test that shows how

Answer 13

blood flows to tissues and organs.

Question 14

what is the use of Tc99m-bisphosphonates ?

Answer 14

commonly used in bone scintigraphy

Question 15

where do bispohosphonates accumulate ?

Answer 15

sites of bone mineral rearrangement

Question 16

What is the most used PET radioisotope ?

Answer 16

FDG

Question 17

main use of FDG ?

Answer 17

oncology

Question 18

use of FDG in oncology allows us to do _______, ______, _______________

Answer 18

diagnosis

staging

response to tx

Question 19

other uses of FDG other than oncology ?

Answer 19

Neurological disorders

Myocardial viability assessment

identify sites of inflammation

Question 20

What particles are used in nuclear medicine for the purposes of therapy ?

Answer 20

Short range particles (alpha/beta)

Question 21

Main indication of Samarium-153 ?

Answer 21

palliative tx of bone metastasis

Question 22

What is the main indication for Radium-223 ?

Answer 22

Bone metastasis from Prostate cancer

Question 23

What is the main indication of Lutetium 177 ?

Answer 23

NET

Question 24

What type of images are produced from PET ?

Answer 24

3D

Question 25

what is the most used radionuclide ?

Answer 25

Iodine 131

Question 26

Except the thyroid, what other tissues can pick up the iodine 131?

Answer 26

Salivary glands and the gastric mucosa

Question 27

99m Tc- Bisphosphonates are analogues of what ?

Answer 27

Pyrophosphate

Question 28

What cells have an high uptake of 18F-FDG ?

Answer 28

cancer and inflammatory cells

Question 29

What are the particles we find use in therapy ?

Answer 29

Alpha and Beta

Question 30

Sestamibi as POSITIVE tracer detects ;

Answer 30

-Parathyroid adenomas or neoplastic

Question 31

Sestamibi as NEGATIVE tracer detects ;

Answer 31

Myocardial perfusion