Radiation Flashcards
Interaction of Radiation with Cellular organelles happens in a fraction of a ______________
second
Stochastic Effects
Events happen by chance
Deterministic Effects
Events sure to happen
Stochastic Effects probability
(cancer and Genetic mutation) Probability of cancer/genetic mutation increases with increasing dose, but the severity does not depend on the amount of dose.
Deterministic Effects
A Somatic effect that increases in severity with increasing absorbed doses
Deterministic Effects are shown as
cataract, skin erythema, fibrosis, and abnormal growth. ( not from diagnosis radiology. (higher the temp, worse is the burn. Longer the contact, worse is the burn)
If radiation damage to the DNA is severe enough the chromosomes can be _____________
Altered
If enough cells undergo similar changes tissues organs can be _______________
damaged
Types of Damage depends on stage of ______ ______
Cell Cycle
Different kinds of ___________ can happen from radiation damage
mutation
Mis-repaired chromosomes can lead to _____________ or slow __________ _________
lead to cell death or slow cell division
Rapid Proliferation of cells may cause ____________ _________
Malignant Development
Ionizing Radiations also affect cell division resulting in _______________
arrested mitosis and retardation of growth
As a cell repairs itself, higher total dose of radiation is needed for cell killing when radiation is delivered in fractionated manner than a single large dose
Cell Recovery
Radiation is a two edged sword:
Causes cancer, kills cancer
Rapidly dividing cells are more sensitive to radiation than
Differentiated slowly dividing cells
Stem cells are radiosensitive and mature cells are
radio-resistant
Tissues with high metabolic rate are
radiosensitive
A high proliferation rate for cells and high growth rate for tissues result in
increased radio sensitivity
Somatic Effects include responses of all types of cells except ______
germ cells of the reproductive system
Genetic effects include responses of irritated
reproductive cells
Genetic Effects are harmful when they are passed onto the
future generations
Genetic Effects are no consequence in persons who will not have
a baby
The time between radiation exposure and visible changes is __________ Period
Latent
Latent period can have a timeline of _________ or ________ latent period
Short or Long
Short term Effects of Latent Period
Minutes, Days, or Weeks
Long Term Effects of Latent Period
Years or Generation
After Latent Period, shoe changes are observed as
Temporary or Permanent
Recovery Period happens when
Recovery can happen after short term effects, cells can repair
May not be immediate clinically observable effects
Somatic Effects
There may be a time lapse before any effects are seen
Somatic Effects
Acute somatic Effects appear
Rather soon after exposure to a single massive does of radiation or after several smaller doses of radiation delivered within a relatively short period of time
Effects which appear within 60 days of exposure to radiation are classified as _________ ___________
Acute Effects
Delayed Somatic Effects may occur
anywhere from two months to as late as 20 years or more after exposure to radiation
The term latent period is usually used only in
relation to stochastic effects (malignancy)
Most Sensitive Variables in Somatic Effects
Lymphocytes, blood forming cells (bone Marrow), Germ Cells
Moderately Sensitive Somatic Effects
Skin Cells, gastrointestinal cells, oral mucosa, lens of the eye
Lease Sensitive Variables in Somatic Effects
Mature Bone Cartilage, Neurons, muscles
Total Dose:
The higher the does of radiation, the greater the severity and probability of occurrence of biological effects.
Dose Rate Dependence:
Radiation dose that would be lethal if given in a short time, such as a few hours, may result in no detectable effects if given in a small increments during a period of several years.
Dose Rate Dependence is due to the ability of
Somatic cells to repair damage caused by exposure to radiation
Tissues do not return to their original state following
Radiation damage, as there are some irreparable alterations produced
Threshold Response:
An increase in radiation dose (curve) may not produce an observable effect until the tissue has received a minimal level of exposure called the threshold dose.
Once the threshold dose has been exceeded,
Increasing dose will demonstrate exceeding observable tissue damage
A well known threshold response is
cataract and erythema of skin
Linear Response
all exposure carries a certain probability of harm and that the effects of multiple small doses are additive.
Linear Dose Response says there is no safe _________
Dose
Linear Dose Response says every exposure carries some
Risk