Radiation Flashcards
Interaction of Radiation with Cellular organelles happens in a fraction of a ______________
second
Stochastic Effects
Events happen by chance
Deterministic Effects
Events sure to happen
Stochastic Effects probability
(cancer and Genetic mutation) Probability of cancer/genetic mutation increases with increasing dose, but the severity does not depend on the amount of dose.
Deterministic Effects
A Somatic effect that increases in severity with increasing absorbed doses
Deterministic Effects are shown as
cataract, skin erythema, fibrosis, and abnormal growth. ( not from diagnosis radiology. (higher the temp, worse is the burn. Longer the contact, worse is the burn)
If radiation damage to the DNA is severe enough the chromosomes can be _____________
Altered
If enough cells undergo similar changes tissues organs can be _______________
damaged
Types of Damage depends on stage of ______ ______
Cell Cycle
Different kinds of ___________ can happen from radiation damage
mutation
Mis-repaired chromosomes can lead to _____________ or slow __________ _________
lead to cell death or slow cell division
Rapid Proliferation of cells may cause ____________ _________
Malignant Development
Ionizing Radiations also affect cell division resulting in _______________
arrested mitosis and retardation of growth
As a cell repairs itself, higher total dose of radiation is needed for cell killing when radiation is delivered in fractionated manner than a single large dose
Cell Recovery
Radiation is a two edged sword:
Causes cancer, kills cancer
Rapidly dividing cells are more sensitive to radiation than
Differentiated slowly dividing cells
Stem cells are radiosensitive and mature cells are
radio-resistant
Tissues with high metabolic rate are
radiosensitive
A high proliferation rate for cells and high growth rate for tissues result in
increased radio sensitivity
Somatic Effects include responses of all types of cells except ______
germ cells of the reproductive system
Genetic effects include responses of irritated
reproductive cells
Genetic Effects are harmful when they are passed onto the
future generations
Genetic Effects are no consequence in persons who will not have
a baby
The time between radiation exposure and visible changes is __________ Period
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