RABIES

Question 1

TRUE OR FALSE: Transmission has resulted from corneal transplantation and also from solid-organ transplantation and a vascular conduit (for a liver transplant)

Answer 1

TRUE

Question 2

Incubation period of rabies

Answer 2

20–90 days

Question 3

The most characteristic pathologic finding in rabies

Answer 3

Negri bodies

• Negri bodies are eosinophilic cytoplasmic inclusions in brain neurons that are composed of rabies virus proteins and viral RNA.
• commonly observed in Purkinje cells of the cerebellum and in pyramidal neurons of the hippocampus

Question 4

Diagnostically useful specimens include _____?

Answer 4

Serum
CSF
Fresh saliva
Skin biopsy samples from the neck, and brain tissue

• Corneal impression smears are of low diagnostic yield

Question 5

Healthy dogs, cats, or ferrets may be confined and observed for ____ days. PEP is not necessary if the animal remains healthy during this period.

Answer 5

10 days

Question 6

TRUE OR FALSE: The use of PEP may be warranted when a person (e.g., a small child or a sleeping adult) has been present in the same space as a bat and an unrecognized bite cannot be reliably excluded.

Answer 6

TRUE

Question 7

Ideally, the first dose of post-exposure prophylaxis should be given as soon as possible after exposure. Three additional doses should be given on days __, __, and __

Answer 7

Days 3, 7, and 14

• a fifth dose on day 28 is no longer recommended

Question 8

Primary schedule of pre-exposure prophylaxis consists of three doses of rabies vaccine given on days

Answer 8

Days 0, 7, and 21 or 28.