Rabbits Flashcards
What is a common GI presentation/symptom in rabbits?
Gut stasis (symptom, not a diagnosis)
Is gut stasis painful? Can gut stasis be fatal in rabbits?
Yes - painful and can be fatal
What is the pathogenesis of gut stasis?
Caused by anorexia
Anorexia causes slowing down of gut motility
Reduction of faecal production
Deteriorating cycle until eating and defaecating stops
Is a rabbit with gut stasis a suitable candidate for anaesthesia?
No
Electrolytes not predictably absorbed/secreted - causes electrolyte derangements
How does gut stasis cause dehydration?
Interstitial fluid moves from tissues into gut
What are the symptoms/history of gut stasis?
Reduced/absent appetite
Reduced/absent faecal production
Lethargy
What is heard on abdominal auscultation in a rabbit with gut stasis?
Reduced gut sounds
May hear abnormally loud borborygmi
What can be felt on abdominal palpation of a rabbit with gut stasis? (more than 1 presentation)
‘Empty’ abdomen if guts not normally filled
OR dilated/fluid filled gut loops
OR impactions of viscera
May be painful
Is gut stasis a disease?
No - a symptom
Important to diagnose the cause as well as treating the gut stasis itself
How is gut stasis diagnosed?
History - reduced appetite and faecal production, lethargy
Gut auscultation - lack of gut sounds or loud borborygmi
Abdo palpation
Imaging, surgery
How is blood glucose linked to GI blockage in rabbits?
Elevated blood glucose causes suspicion of GI blockage
HOWEVER poor sensitivity/specifity - not all blocked show high glucose, and not all hyperglycaemic rabbits are blocked
What is the treatment for gut obstruction in rabbits?
Surgical intervention (once stabilised)
Give examples of good surgical technique in rabbits
Minimise direct handling
Used moistened swabs
Use wet, non-powdered gloves
Ensure good homeostasis
Should prokinetics be given in the case of rabbit obstruction or after gut surgery?
NO - contraindicated
What is dysbiosis in rabbits?
Alteration in gut bacteria
What can cause dysbiosis in rabbits?
Antibiotic use - care with which you use
Altered body temperature
Change in gut motility (gut stasis)
Drastic diet alteration
What are the clinical signs of dysbiosis in rabbits?
Change in faecal consistency
Altered appetite
Possible production of bacterial endotoxins (C. prevail)
What is the treatment for dysbiosis?
Aggressive treatment of underlying cause
Adsorbents - choletsyramine, activated charcoal
Gut stasis can lead to dysbiosis. Which is more serious?
Dysbiosis potentially much more serious than gut stasis alone
What is failure to eat caecotrophs commonly misdiagnosed as?
Diarrhoea
Do rabbits that fail to eat caecotrophs still have normal faeces?
Yes - still produce normal hard faeces
What can cause failure to eat caecotrophs?
Change in taste - diet change, medications, infection
Change in consistency - may be more runny than usually if infection/inflm of caecum
Inability/unwilling to turn around and eat them - pain, dental disease, spondylosis, osteoarthritis, poor balance due to inner ear disease
Is diarrhoea serious in the rabbit?
Yes - true emergency!
Why is diarrhoea so serious in rabbits?
Gut motility seriously disordered
Rapid fluid loss
Significant electrolyte imbalance
What can cause diarrhoea in rabbits?
Protozoan parasites - coccidia
Bacterial infection and endotoxin production - Tyzzer’s disease (C. piliformis)
Mucoid enteropathy
What is mucoid enteropathy? What age rabbits is it usually seen in?
Distinct diarrhoea complex
SI and LI dilated with mucoid diarrhoea
Usually juvenile rabbits
What/are histological changes seen with mucoid diarrhoea?
Few/no histological changes seen
What is the cause and treatment for mucoid enteropathy?
Unknown agent - may co-exist with other GI infections e.g. coccidiosis
Thought to be contagious
Treatment unrewarding
What is the definition of bloat in rabbits?
Gut loops filled with gas
Intensely painful
What causes bloat in rabbits?
Bacteria within gut produce gas when multbiome or diet changes
What can bloat in rabbits lead to?
Functional obstruction of pyloric outflow - gastric dilatation
(Rabbit stomachs do not usually progress to torsion)
What is the treatment for bloat?
May require surgery to allow gas to pass out of the stomach
With caecal impaction, does the animal continue to defaecate normally?
Produces normal hard faeces
But NO caecotrophs are passed
Describe the pathology and sequelae of caecal impaction
Caecum fills with ingesta and fails to empty
Caecum gets progressively more and more full –> pain
As no caecotrophs, rabbit loses weight due to lack of calories/nutrients
Is there a treatment for caecal impaction?
Not really
PGF-2a suggested - but not very helpful
What age of rabbits is typically affected by coccidiosis?
Weanlings
(Rare in adults
Kits immune prior to weaning)
What are risk factors for coccidiosis?
Poor hygiene
Overstocking
Stress
Is coccidiosis infection and disease common?
Infection common
But disease relatively rare - each species has different pathogenicity and different area of predilection
What are the clinical signs of enteric coccidiosis?
Diarrhoea - possibly with mucus/blood
Stunting, weight loss, lethargy, anorexia, death
What are the clinical signs of hepatic coccidiosis?
Weight loss, stunting, ascites, jaundice hepatomegaly
May be subclinical
What are the 2 forms of coccidiosis in rabbits?
Enteric
Hepatic
Is routine worming indicated for most rabbits in UK?
No
Passalurus ambiguus is a common pinworm in rabbits. Is it always pathogenic?
No - part of multi-biome
Potentially helps in caecal contents mixing/digestion
Rabbits can be intermediate the intermediate host for various species of worm?
Taenia spp
Tapeworm
In what type of rabbits is the Obeliscoids cuniculi worm found? Where in the body is it found?
Wild rabbits
Stomach worm
What is dysautonomia (also referred to as megacolon) in rabbits?
Dysfunction of autonomic system
Degenerative changes in autonomic neurones
What age of rabbit is usually affected by dysautonomia?
Weanlings most affected
Adults can be affected
What is the biggest risk factor for dysautonomia in rabbits?
Low fibre diet
But cause unknown
What are the clinical signs of dysautonomia?
Pain
Large bowel impaction (palpable)
Reduced gut function - stomach and caecum do not empty
May have swallowing difficulties and urinary incontinence
Is there treatment for dysautonomia in rabbits?
No effective Tx
Don’t use oral meds - risk of inhalation pneumonia
When are prokinetics contraindictated in rabbits?
If gut obstruction
After gut surgery (where the lumen of guts has been opened)
Give examples of pro kinetics that can be used in rabbits (not after GI surgery or gut impaction)
Metoclopramide
Cisapride
Ranitidine
Domperidone
Should a rabbit be given supportive feed if it is not eating?
Yes - until voluntary eating returns, to ensure gut function and motility maintained
(As long as not obstructed)
Any rabbit that is not eating voluntary is presumed to have what % of dehydration?
5%
Fluids in a rabbit can be given IV, IO, SC or orally . What rate should they be given?
Same as other small animals
2-4ml/kg/hr
Should pre and probiotics be given to rabbits?
Evidence for and against use - worst case is they don’t work and don’t influence the gut bacteria
Unlikely to cause harm
What type of teeth do rabbits have?
Hypsodont - no true root, have reserve crowns
Elodont - open rooted, constantly growing
Rabbits are diphyodont. What does this mean?
2 sets of teeth
1st set lost at/around birth - should never be seen clinically
At what rate do teeth grow in the rabbit?
1-3mm/week depending on which tooth
What are causes of dental disease in rabbits?
Congenital - malocclusion
Acquired - anorexia from whatever cause
Trauma - fractured teeth or jaw
What are the clinical signs of dental disease in rabbits?
Anorexia
Drooling
Teeth grinding
Wet below chin/on front paws
Change in dietary preference - can tell you where the problem is
May be no clinical sign at all until problems advanced
What is the treatment for dental disease in rabbits?
Make sure gut is working
Correct fluid/electrolyte imbalances
Provide analgesia
Once rabbit is stable, can consider GA, dental x-rays and burring teeth
Why should nail clippers or dental clippers not be used to trim rabbit teeth? What should be used instead?
Predisposes to sharp edge and fractures (longitudinally down tooth)
Can result in tooth root abscesses
Why are dental x-rays important in rabbits?
2/3 of tooth within jaw - you can’t see what’s going on until x-ray
Allows you to build a 3D image and plan treatment
Abscesses are common in rabbits. What can they be caused by?
Secondary to trauma/bite wounds
Post-surgery
Related to dental disease
What is the best treatment for abscesses?
Radical/complete surgical excision
Primary closure of clean wound (if possible)
Removing affected teeth if dental abscess
Long course of antibiotic - PMMA beads
(Not lancing)
Why are rabbits prone to pododermatitis?
No footpads
Furred plantar surfaces
What factors predispose a rabbit to pododermatitis?
Obeisty
Soiled bedding
Wire floors
Rex breed
What is the treatment for pododermatitis in rabbits?
Treat secondary infection
Analgesia, antibiotics
Surgical intervention if severe
Provide deep bedding
What is barbering in rabbits?
Rabbit repeatedly plucking hair from itself or others
Why may rabbits do barbering?
Dominance
Insufficient dietary fibre
What is the ear mite in rabbits?
Psoroptes caniculi
What is the waling dandruff mite in rabbits?
Cheyletiella parasitovorax
surface mites, large white scales
What species cause fleas in rabbits?
Ctenocephalides felis
C. canis
Spilopsyllus caniculi
How are fleas treated in rabbits?
Imidocloprin - licensed
NOT fipronil = toxicity
In what season does myiasis (flystrike) occur in rabbits?
Summer
Does myiasis (flystrike) occur on normal skin?
No
How is myiasis (flystrike) prevented in rabbits
Cyromazine (Rearguard)
What species of fly causes myiasis (flystrike)?
Lucilia spp
L2 larvae
What is the treatment for flystrike/myiasis?
Sedation for thorough examination Analgesia Clip and clean lesions Insecticidal Ivermectin Surgical intervention/debridement may be required in severe cases
What is the etiological agent for rabbit syphilis?
Treponema cuniculi
What are the clinical signs of rabbit syphilis (Treponema cuniculi)?
Genital lesions
Facial lesions - lips, eyelids
How is rabbit syphilis transmitted and treated?
Sexually transmitted
Tx with parenteral penicillin
What etiological agent causes myxomatosis?
Poxivirus
Transmitted by insect vectors
What are the two forms of myxomatosis?
Systemic form - facial and genital oedema
Cutaneous forms
What fungal species can cause ringworm in rabbits?
Trichophyton metagrophytes
Microsporum canis
ZOONOTIC
What are the clinical signs of ringworm in rabbits?
Crusty, erythematous alopecia +/- pruritis
Seen in young animals with high stocking densities
How are calici viruses in rabbits diagnosed?
Post-mortem
PCR on suitable tissue e.g. liver
What is the reservoir for RHD-1 in rabbits?
European brown hair
What are the relative mortality rates for RHD-1 and RHD-2 in rabbits?
RHD-1 high mortality
RHD-2 lower mortality rates, longer incubation (but similar clinical signs)
What are the clinical signs of RHD-1 in rabbits?
Acute death Febrile Severely lethargic May bleed from nose/mouth Reverse age susceptibility - young immune until 5-6 wks
What is the etiological agent of ‘snuffles’ in rabbits?
Pasteurella multocida
+/- other pathogens
Related to stress, husbandry and strains of bacteria present
What are the clinical signs of ‘snuffles’ in rabbits?
Related to upper respiratory system - nasal discharge, sneezing
Coughing rare
May see abscesses, balanoposthitis, pyometra depending on route of infection
What is the diagnosis and treatment of respiratory disease in rabbits?
Dx: deep nasal swabs, radiographs
Tx: antibiotics, NSAIDs, fluids, supplemental oxygen, decongestants
Correct husbandry and potential stressors
What conditions can cause a head tilt in rabbits?
Encephalitozoon cuniculi (protozoa)
Ear infection
Respiratory infection tracking up to middle ear via Eustachain tube
Neurological problem
Meclizine and prochlorperazine are what type of drugs?
Anti-vertigo drugs
Reduce dizziness and head tilt
How can the protozoa Encephalitozoon cuniculi be transmitted?
Ingestion
Inhalation
Transplancetal
What forms of disease can Encephalitozoon cuniculi cause?
Neurological disease
Renal disease
What is the treatment for E. cuniculi?
Fenbedazole effecting at removing organisms
But clinical signs may persist for yrs after
What biochem parameter is key for assessing renal disease in rabbits?
Phosphorus
How is most calcium excreted in rabbits?
In urine
Suspended, not dissolved
What is urine sludging in rabbits?
Thick paste urine
Due to calcium in urine settling onto ventral bladder wall (if calcium mobility restricted)
How can urine sludging in rabbits be treated?
Flushing bladder
Medications that alter solubility of calcium salts - you cannot acidify herbivore urine
Fluids!!!
Dietary modification
How is urolithiasis treated in rabbits?
Surgery
Correct underlying causes
Dietary manipulation
What are the clinical signs of phantom pregnancy in rabbits?
Nesting
Fur pulling
Lactation
Give 2 examples of infectious abortion agent sin rabbits
Pasturella
Treponema
How does uterine adenocarcinoma develop in rabbits?
Repeated empty cycles predispose uterine tissue to become neoplastic
Hyperplasia –> adenoma –> adenocarcinoma
What causes mammary neoplasia in rabbits?
Intact females
Ovarian remnants post-spay
Describe the pathogenesis of adrenal disease in rabbits (similar to ferrets)
Gonadotrophins (LH, FSH) remain at stimulatory levels in blood after neutering
No gonads to act on
Receptor formation on adrenal surface = stimulated adrenal glands
(Similar to ferrets)