RAAS Flashcards
What is renin?
an enzyme
What is Angiotensinogen, where is it produced, and where is it found?
A large protein produced by the liver that circulates in blood
Where can you find Angiotensin Converting Enzyme (ACE)?
Endothelial cells of the lungs
-converts the Angio I into a potent hormone called ANGIOTENSIN II
side note:
ACE inhibitors work on this system and are used to protect the kidneys from HBP damage over time
Where are Angiotensin II receptors found?
Smooth muscles of blood vessels
-reception will cause vasoconstriction of these vessels and cause increased resistance
-Bind the receptors on the efferent arterioles of the kidneys (afferent arterioles don’t have many receptors and will only constrict when lots of Angio II is present)
-efferent constriction results in more blood remaining in the glomerulus, “preserving” GFR
-afferent and efferent constriction results in decreased GFR and renal blood flow to conserve blood volume
What else does Angiotensin II do?
Binds to receptors of PCT which activates reabsorption of more Na+/water
speaks to the hypothalamus, which increases thirst and releases ADH (causing water reabsorption in the DCT and collecting duct)
What else does Angiotensin II do?
Binds to receptors of PCT which activates reabsorption of more Na+/water
speaks to the hypothalamus, which increases thirst and releases ADH (causing water reabsorption in the DCT and collecting duct)
What determines blood pressure?
total circulating blood volume (x) total body resistance
(resistance=constriction essentially)
what is aldosterone?
A mineral corticoid
