RA tx Flashcards

1
Q

What are the current treatment options for RA?

A
  • NSAIDS
  • Corticosteroids
  • Syntheitc DMARDs
  • Biologic DMARDS
  • Combination therapy
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2
Q

NSAIDS

A
  • still in use, high ulcer risk, higher cardiovascular risk
  • Pros: control pain/inflamm, dec swelling, improve function, improve QOL, cheap

Cons: doesn’t affect progression, GI toxicity, hepatic dysfunction, renal complications, CNS toxicity

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3
Q

Corticosteriods

A

-IV or oral
-may have disease modifying effect
bridge while awaiting DMARD effect
-used for major flares
-low does alternative to NSAIDS
-use lowest does possible

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4
Q

Methotresate- Rhematrex

A
  • 1st line agent, start 7.5mg/wk inc to 15-25mg over 6-8 wks
  • Purine antagonist, document to decrease erosion of bone
  • reduction of T-cell proliferation –> inc adenosine release –> alter expression of cytokines
  • slows course of diseas, anchor in combos
  • liver/lung/GI toxicity
  • Can be used aggressively: greater improvement in tender joint count and swollen joint count. 20 mg vs 10 mg
  • Before using: ask about alcohol, pregnancy, chrck renal/liver function
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5
Q

Leflunomide- Arava

A
  • Pyrimidine antagonist; long half life
  • liver toxicity, diarrhea, HTN,
  • dec jount damage, slows progression
  • blocks T cell clonal expansion
  • avoid getting pregnant–> teratogenic
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6
Q

Sulfasalazine- Azulfidine

A
  • disease modification
  • can induce leukopenia–> greater risk for infrection
  • used in combo regimens
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7
Q

Hydroxychloroquine- Plaquenil

A
  • used for milder cases; part of combo

- diarrhea/skin rash are side effects

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8
Q

Biologic Response Modifiers

A
  • very effective/expensive

- can be toxic

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9
Q

Monoclonal Antibodies

A
  • Large molecules, synthesized by animals or cells
  • directed at cytokine or cell receptor
  • neutralize the action of cytokine or cell or kill cell
  • very expensive
  • end in “MAB”
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10
Q

What does TNF do?

A
  • stimulates cytokine production including IL-6 and TNF

- inhibits bone formation and stimulates resportion

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11
Q

What is Etanercept- Enbrel

A
  • Soluble TNF-receptor from fusion of TNF-aplha to human Fc portion of IgG
  • BINDS AND INACTIVATES FREE TNF-aplha
  • biologic response modifier
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12
Q

What is Infliximab- Remicade (I.V.)

A
  • Chimeric mouse/human Monoclonal Antibody
  • anti- TNF–> binds soluble and cell surface TNF
  • 3mg/kg, administered by IV
  • used with MTX or Arava

-bio-modify

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13
Q

Adalimumab- Humira

A
  • Human monoclonal anti-TNF antibody

- bio-modify

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14
Q

Golimumab- Simponi

A
  • recombinant fully human monoclonal anti-TNF antibody

- bio-modify

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15
Q

Certolizumab pegol - Cimza

A
  • PEGylated Fab fragment of humanized anti TNF antibody
  • lacks FC fragment so it does not activate complement or antibody dependent cytotoxicity
  • benefit may be seen as early as 1 wk
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16
Q

What does IL-1 alpha or IL-1 beta do

A
  • increase cytokines/chemkines/PG/MMP production/release
  • activates osteoclasts
  • promotes endothelial cell adhesion
17
Q

Anakinra-Kineret

A
  • bioloigc modifier
  • IL-1 receptor antagonist; IL-1 mediates joint erosion
  • 100mg daily
  • works for gout/adult stills disease
18
Q

what does IL-6 do?

A
  • Stimulates immunoglobulin synthesis by B cells
  • Stimulates cytotoxic T cell differentiation
  • Stimulates production of CRP and SAA from liver
19
Q

Tocilizumab (Actemra)

A
  • Humanized anti-IL 6 receptor antibody whic blocks membrane-bound and soluble IL-6 receptor
  • bio-modify
20
Q

Rituximab (Rituxan)

A
  • Chimeric anti-CD 20 antibody which depletes B cell population
  • blocks B cells
  • monoclonial antibody
21
Q

Abatacept (Orencia)

A
  • Inhibits T cell activation by binding to co-stimulatory molecules CD 80 and CD86
  • blocks second signal required for T cell activation by limiting APC interaction c T cells
22
Q

Denosumab (AMG 162)

A

-Fully human anti-RANKL monoclonal antibody
-RANKL promotes bone erosion
-

23
Q

What are the safety considerations with TNF antagonists?

A
  • Serious infections
  • TB
  • lymphoma