RA Flashcards
Women with RA got better during pregnancy when on ___
corisone
Where in the immune system does cortisone hit
literally everything
IgG production, differentiation, migration, antigen presentation, cytokine production
Adverse effects of glucocorticoids excess:
CUSHINGOID
cataracts, ulcers, striae/skin thinning, hypertension and hirsutism, immunosuppression and infections, necrosis of femoral heads, glucose elevation, osteoporosis and obesity, impaired wound healing, depression mood changes
What are the 4 synthetic DMARDs for RA
Methotrexate
sulfasalazine, hydrochloroquine, leflunomide
MOA of methotrexate
inhibit dihydrofolate reductase-> impaired purine production
Methotrexate is used for RA and also ___ at a higher dose
cancer
Side effects of methotrexate
nausea, fatigue, increased LFTs, bad CBC, mouth sores, alopecia, pneumonitis
What are 4 big categories for bDMARDs
TNF inhibitors, IL6 inhibitors, recombinant CTLA-4 fusion protein, JAK inhibitors (also anti-cd20, anti-il1)
Comorbidities of RA
CVD, osteoporosis, T2DM
What are the 5 TNF inhibitors used
adalimumab, etanercept, infliximab, golimumab, certolizumab
What are 2 IL6 inhibitors
Tocilizumab, sarilumab
What is the recombinant CTLA-4 fusion protein
Abatacept
What is the anti-IL1 used
anakinra
All DMARDs are immunosuppressive except for ___
hydroxychloroquine
New DMARDs work better when combined with ___
methotrexate
